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Effect of bicarbonated Ringer's solution on PaCO2 and tissue PO2 in hemorrhagic shock rats
Critical Care volume 10, Article number: P178 (2006)
Background and objectives
Bicarbonated Ringer's solution (BRS) is considered to be an ideal extracellular fluid solution because it contains bicarbonate, which does not need metabolic processes to exert alkalinizing effect. But administration of a large amount of BRS arouses concern about negative effects of acute alkalinizing such as metabolic alkalosis and a leftward shift of Hb-O2 saturation curves. In this study, we observed an impact of a large amount of BRS on PaCO2 and tissue PO2 during hemorrhagic shock.
Fifty male SD rats were divided into five groups: a sham-operated group (Sham), hemorrhagic shock without infusion (HS group), hemorrhagic shock with infusion of normal saline (NS group) and bicarbonated and acetated Ringer's solutions (BRS and ARS groups). Thirty minutes after hemorrhage (2 ml/100 g), resuscitation fluids (three times as much as bleeding) were administered over 30 min. The tissue PO2 and laser Doppler tissue blood flow was continuously observed, and blood gas analysis was performed.
HCO3- decreased in all the hemorrhagic groups. HCO3- increased in the BRS and ARS groups after resuscitation, while it kept decreasing in the NS group. PaO2 and PaCO2 recovered to their control values after infusion. PaO2 kept increasing more, but PaCO2 gradually decreased after resuscitation.
Even if BRS was infused to large amounts for the hemorrhage shock, metabolic alkalosis did not occur. The difference was not seen on the tissue PO2 among the resuscitation groups. The repression of breathing was not suggested from this result.
Satoh K, Ohtawa M, et al.: Pharmacological study of BRS, a new bicarbonated Ringer's solution, in haemorrhagic shock dogs. Eur J Anaesthesiol 2005, 22: 703-711. 10.1017/S026502150500116X
Mulier KE, Beilman GJ, et al.: Ringer's ethyl pyruvate in hemorrhagic shock and resuscitation does not improve early hemodynamics or tissue energetics. Shock 2005, 23: 248-252.
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Suzuki, S., Hitosugi, T., Shimizu, T. et al. Effect of bicarbonated Ringer's solution on PaCO2 and tissue PO2 in hemorrhagic shock rats. Crit Care 10 (Suppl 1), P178 (2006). https://doi.org/10.1186/cc4525
- Hemorrhagic Shock
- Metabolic Alkalosis
- Tissue Blood Flow
- Doppler Tissue