- Meeting abstract
Ecological and economic impact of ceftazidime and probabilist antibiotherapy limitation strategy in ventilator-associated pneumonia
Critical Care volume 1, Article number: P039 (1997)
Aims of the study
In our intensive care unit, the ventilator-associated pneumonia coefficient and density of incidence were respectively 21 for 100 ventilated-patients, and 20 for 1000 days of ventilation. In 1995, we had observed an increase of ceftazidime-resistant Pseudomonas aeruginosa frequency. We, therefore, compared the ecology and the cost of antibiotherapy between the first 1995 semester and the first 1996 semester, after we prescribed less of ceftazidime, and we limited the probabilist treatment in only at risk patients.
Patients and methods
For suspicion of ventilator-associated pneumonia in patients presenting the criteria of Andrews we realized 75 bronchiolo-alveolar lavages in the first 1995 semester (GI) and 70 in the first 1996 semester (G2). The diagnosis of this pneumonia was positive when bacteriologic quantitative cultures were > 104 cfu/ml.
Between the two periods the total cost of antibiotherapy and the cost of beta-lactamins respectively decreased to 15 and 25%.
Our strategy was favourable for ecology and economy in our intensive care unit. These results must be confirmed during the 2 complete years.
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Cite this article
Gruson, D., Hilbert, G., Favier, J. et al. Ecological and economic impact of ceftazidime and probabilist antibiotherapy limitation strategy in ventilator-associated pneumonia. Crit Care 1 (Suppl 1), P039 (1997). https://doi.org/10.1186/cc45