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Superimposed high-frequency jet ventilation and oleic-acid-induced acute lung injury piglets: an experimental study

Superimposed high-frequency jet ventilation (SHFJV) is a special form of combined high-frequency jet ventilation described in other studies as an effective respiratory therapy of acute lung injury (ALI) patients. We compared this technique with conventional mechanical ventilation in oleic-acid-induced ALI piglets over a study period of 5 hours. After ALI induction, 18 pigs were randomly assigned to three groups. A SHFJV group with a high-frequency (500 bpm) and a low-frequency (15–20 bpm) jet stream and a PEEP of 10 cmH2O; a CPPV group (continuous positive pressure ventilation) presenting VT = 10 ml/kg, I:E = 1:1, PEEP = 10 cmH2O; and a IPPV group (control group; intermittent positive pressure ventilation) VT = 10 ml/kg, I:E = 1:1, zero PEEP. SHFJV animals showed an earlier and more efficient improvement in oxygenation compared with group B (90 vs 180 min; PaO2 70.5 ± 11.3 vs 41.2 ± 7.9 kPa) despite lower mean airway pressures applied (16 ± 1.4 vs 22 ± 1.8 mbar). CO2 elimination was also more effective (6.0 ± 1.4 vs 8.2 ± 1.6) although peak airway pressures were the lowest (30 ± 3.8 vs 45 ± 4.6 mmHg). SHFJV may therefore be useful in ALI management.

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Rezaie-Majd, A., Ihra, G., Kraincuk, P. et al. Superimposed high-frequency jet ventilation and oleic-acid-induced acute lung injury piglets: an experimental study. Crit Care 10, P23 (2006). https://doi.org/10.1186/cc4370

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Keywords

  • Public Health
  • Experimental Study
  • Mechanical Ventilation
  • Emergency Medicine
  • Special Form