Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study

Table 1 Initial clinical characteristics of the 16 patients

	Patients without septic shock
	1	2	3	4	5	6	7	8
Age	26	35	67	69	35	25	55	48
SAPS	17	9	17	13	10	10	12	12
LISS	2.3	3	3	3	2.3	2.8	2.5	3
Outcome	S	S	D	D	S	S	D	S
Cause of ARDS	BPN	BPN	BPN	BPN	Pulmonary contusion	BPN	Mesenteric infarction	BPN
COPD	No	No	Yes	No	No	No	Yes	No
% of lung consolidation	63	51	72	43	55	64	89	nd
CT scan abnormalities	BCLL	BCLL	BCLL	BCLL	BCLL + DPH	BCLL + DPH	DPH	nd
	Patients with septic shock
	9	10	11	12	13	14	15	16
Age	17	59	61	42	63	47	67	67
SAPS	6	8	10	16	5	7	10	14
LISS	2	2.8	3.5	3	1.8	2	2.8	2.5
Outcome	S	S	D	S	S	S	S	D
Cause of ARDS	BPN	BPN	BPN	Peritonitis	Post CPB	BPN	BPN	Septic shock
COPD	No	Yes	No	No	No	No	No	Yes
% of lung consolidation	49	72	70	50	57	58	49	48
CT scan abnormalities	BCLL	BCLL + DPH	BCLL	BCLL	BCLL	BCLL + DPH	BCLL + DPH	BCLL

S = survived; D = deceased; BPN = bronchopneumonia; LISS = lung injury severity score; SAPS = simplified acute physiologic score; ARDS = acute respiratory distress syndrome; COPD = chronic obstructive pulmonary disease; nd = not determined (unstable spine fractures); BCLL = bilateral consolidation of lower lobes; DPH = disseminated `patchy' hyperdensities; CPB = cardiopulmonary bypass.

ISSN: 1364-8535