A comparison of transcranial Doppler with near infrared spectroscopy and indocyanine green during hemorrhagic shock: a prospective experimental study

Table 1 Hemodynamic data, blood gases and NIRS values at the different experimental stages

Hemodynamic variables and blood gases	Baseline (n = 20)	Baseline therapy (n = 20)	Therapy + 10 min (n = 19)	Therapy + 40 min (n = 15)	Therapy + 90 min (n = 15)
CPP (mmHg)	70 ± 16	16 ± 5^a	34 ± 16^a,b	43 ± 16^a,c	46 ± 20^a,c
HR (beats·min^-1)	99 ± 22	193 ± 27^a	194 ± 30^a	202 ± 32^a	200 ± 35^a
CO (l·min^-1)	5.8 ± 1.3	2.0 ± 0.5^a,d	2.9 ± 0.7^a,d	3.6 ± 1.3^a,b,d	6.2 ± 2.0
ICP (mmHg)	14 ± 4	9 ± 3^a	9 ± 3^a,e	11 ± 2	13 ± 2^b
PaO₂ (mmHg)	152 ± 36	141 ± 19	434 ± 45^a,c,d	230 ± 27^a,c,f	233 ± 16^a,c
PaCO₂ (mmHg)	41 ± 5	35 ± 3^a	48 ± 4^a,c	51 ± 4^a,c	48 ± 4^a,c
NIRS variables after ICG injection	n = 18	n = 18	n = 17	n = 13	n = 10
Time interval (0–100%; s)	7.5 ± 1.1	16.7 ± 5.4^a	7.6 ± 2.2^c	5.7 ± 1.4^c	5.1 ± 1.4^c
Rise time (10–90%; s)	4.4 ± 1.1	11.2 ± 3.9^a	4.5 ± 2.1^c	3.1 ± 1^c	3.0 ± 1.0^c
Slope (μmol·l^-1·s^-1)	0.012 ± 0.003	0.005 ± 0.002^a	0.009 ± 0.004^e	0.012 ± 0.005^c	0.014 ± 0.007^c

Data are given as mean ± standard deviation. ^ap < 0.001 versus baseline; ^bp < 0.01 versus baseline therapy; ^cp < 0.001 versus baseline therapy; ^dp < 0.001 versus therapy + 90 minutes; ^ep < 0.05 versus therapy + 90 minutes; ^fp < 0.001 versus therapy + 10 minutes. CO, cardiac output; CPP, cerebral perfusion pressure; HR, heart rate; ICP, intracranial pressure; ICG, indocyanine green; NIRS, near infrared spectroscopy; PaCO₂, arterial CO₂ tension; PaO₂, arterial partial oxygen pressure.

ISSN: 1364-8535