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Table 2 Hemodynamic variables in blood perfused lungs isolated from healthy rats

From: Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture

Hemodynamic variable

Time (minutes)

 

0

30

60

90

120

PPA, cmH2O

     

   Control

22.0 ± 1.6

21.7 ± 1.7

22.4 ± 2.1

24.1 ± 1.9

23.4 ± 2.0

   ET-1

19.7 ± 1.0

18.7 ± 1.3

18.9 ± 1.7

17.5 ± 2.0

 

   ET-1+Tezo

21.7 ± 0.4

21.0 ± 1.6

22.6 ± 1.2

19.8 ± 1.3

22.6 ± 1.6

PLA, cmH2O

     

   Control

14.3 ± 0.8

14.6 ± 0.9

14.6 ± 0.9

14.9 ± 0.8

14.9 ± 0.8

   ET-1

13.1 ± 0.8

13.1 ± 0.9

13.1 ± 0.9

14.7 ± 1.2

 

   ET-1+Tezo

13.1 ± 0.8

13.1 ± 0.9

12.3 ± 0.8

10.9 ± 0.8

12.4 ± 0.8

RT, cmH2O/ml/min

     

   Control

0.58 ± 0.1

0.54 ± 0.1

0.60 ± 0.1

0.69 ± 0.1

0.72 ± 0.1

   ET-1

0.49 ± 0.1

0.42 ± 0.1

0.43 ± 0.1

0.20 ± 0.1

 

   ET-1+Tezo

0.80 ± 0.1

0.75 ± 0.1

0.78 ± 0.0

0.68 ± 0.1

0.78 ± 0.1

ΔPmv, cmH2O

     

   Control

6.5 ± 0.4

6.5 ± 0.4

6.5 ± 0.4

6.5 ± 0.4

6.9 ± 0.4

   ET-1

6.9 ± 0.4

6.9 ± 0.4

6.7 ± 0.4

6.9 ± 0.5

 

   ET-1+Tezo

7.2 ± 0.4

7.2 ± 0.4

7.2 ± 0.4

7.2 ± 0.4

7.3 ± 0.4

  1. Data are presented as mean ± SEM. Control, control group (n = 8); ET-1, endothelin-1 group (n = 7); ET-1+Tezo, endothelin-1+tezosentan group (n = 7). PLA, left atrium pressure; PPA, pulmonary artery pressure; ΔPmv, difference between pulmonary microvascular pressure determined prior to and during a standardized elevation of PLA (7.9 cmH2O); RT, total vascular resistance.
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Critical Care

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