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Table 2 Hemodynamic variables in blood perfused lungs isolated from healthy rats

From: Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture

Hemodynamic variable Time (minutes)
  0 30 60 90 120
PPA, cmH2O      
   Control 22.0 ± 1.6 21.7 ± 1.7 22.4 ± 2.1 24.1 ± 1.9 23.4 ± 2.0
   ET-1 19.7 ± 1.0 18.7 ± 1.3 18.9 ± 1.7 17.5 ± 2.0  
   ET-1+Tezo 21.7 ± 0.4 21.0 ± 1.6 22.6 ± 1.2 19.8 ± 1.3 22.6 ± 1.6
PLA, cmH2O      
   Control 14.3 ± 0.8 14.6 ± 0.9 14.6 ± 0.9 14.9 ± 0.8 14.9 ± 0.8
   ET-1 13.1 ± 0.8 13.1 ± 0.9 13.1 ± 0.9 14.7 ± 1.2  
   ET-1+Tezo 13.1 ± 0.8 13.1 ± 0.9 12.3 ± 0.8 10.9 ± 0.8 12.4 ± 0.8
RT, cmH2O/ml/min      
   Control 0.58 ± 0.1 0.54 ± 0.1 0.60 ± 0.1 0.69 ± 0.1 0.72 ± 0.1
   ET-1 0.49 ± 0.1 0.42 ± 0.1 0.43 ± 0.1 0.20 ± 0.1  
   ET-1+Tezo 0.80 ± 0.1 0.75 ± 0.1 0.78 ± 0.0 0.68 ± 0.1 0.78 ± 0.1
ΔPmv, cmH2O      
   Control 6.5 ± 0.4 6.5 ± 0.4 6.5 ± 0.4 6.5 ± 0.4 6.9 ± 0.4
   ET-1 6.9 ± 0.4 6.9 ± 0.4 6.7 ± 0.4 6.9 ± 0.5  
   ET-1+Tezo 7.2 ± 0.4 7.2 ± 0.4 7.2 ± 0.4 7.2 ± 0.4 7.3 ± 0.4
  1. Data are presented as mean ± SEM. Control, control group (n = 8); ET-1, endothelin-1 group (n = 7); ET-1+Tezo, endothelin-1+tezosentan group (n = 7). PLA, left atrium pressure; PPA, pulmonary artery pressure; ΔPmv, difference between pulmonary microvascular pressure determined prior to and during a standardized elevation of PLA (7.9 cmH2O); RT, total vascular resistance.