Permissive hypercapnia in infants and children with acute respiratory distress syndrome
© BioMed Central Ltd 2001
Published: 1 March 1997
There is increasing evidence that the use of large tidal volumes (Vt) and high peak inspiratory pressures (PIP) during mechanical ventilation (MV) results in severe pulmonary damage. The aim is to present our experience with pressure controlled ventilation (PCV) and permissive hypercapnia (PHC) in paediatric patients with acute respiratory distress syndrome (ARDS).
Prospective case report series.
A 12 bed multidisciplinary paediatric ICU in a University hospital.
From October 1993 to October 1996 paediatric patients (8 males, 2 females) with a mean age of 2.6 ± 1.4 years and a mean body weight of 12.5 ± 4.3 kg suffering from severe ARDS were included into this study. Before starting controlled hypoventilation six patients had signs of pulmonary barotrauma.
All patients were intubated, sedated and paralysed. The goal of mechanical ventilation was to limit PIP to 40 cmH2O and expiratory tidal volume (Vtexp) < 10 ml/kg while titrating PEEP and I : E ratio; FiO2 was reduced to 60–70%; acceptable SaO2 values were at 85%.
Mean duration of MV was 18.7 ± 5.3 days. During controlled mechanical hypoventilation PIP and Vtexp decreased from 41 ± 0.7 to 32 ± 1 cmH2O (P < 0.01), and from 11.6 ± 0.3 to 8.3 ± 0.4 ml/kg (P < 0.01), whereas arterial PCO2 increased from 44 ± 2.2 to 74.4 ± 4.5 mmHg (P < 0.01). Pulmonary barotrauma resolved rapidly in five patients during controlled hypoventilation. However, two patients subsequently needed extracorporeal lung support because of progredient hypoxemia. All but one patient survived.
PHC offers an attractive alternative to conventional MV in paediatric patients with ARDS resulting in improved pulmonary recovery and decreased mortality.