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Table 5 Kidney and liver function

From: Anti-L-selectin antibody therapy does not worsen the postseptic course in a baboon model

  Time (hours)
  -0.5 0 1 2 4 6 10 24 32 48 72
Creatinine (μmol/l)            
   Placebo 86 ± 3 81 ± 5 78 ± 6 80 ± 6 93 ± 6 97 ± 11 133 ± 18 200 ± 48 189 ± 73 112 ± 10 96 ± 7
   L-SEL-Ab 105 ± 6 96 ± 7 88 ± 7 93 ± 5 104 ± 6 109 ± 7 145 ± 16 240 ± 42 276 ± 65 226 ± 90a 121 ± 12
Urine output (ml/h)            
   Placebo nd 43.8 ± 11.0 31.9 ± 9.3 63.75 ± 29.0 111.3 ± 95.8 124.4 ± 34.3 84.4 ± 17.5 87.1 ± 27.2 80.8 ± 25.0 69.0 ± 12.6 nd
   L-SEL-Ab nd 36.88 ± 11.1 38.1 ± 12.3 66.9 ± 26.4 161.9 ± 42.0 122.5 ± 41.1 94.4 ± 25.6 79.4 ± 16.4 55.0 ± 7.2 72.0 ± 7.3 nd
BUN (mg/dl)            
   Placebo 12.7 ± 1.2 12.1 ± 1.3 13.2 ± 1.3 12.2 ± 1.4 11.7 ± 1.4 11.9 ± 1.2 17.9 ± 2.0 30.8 ± 1.8 34.1 ± 4.3 38.0 ± 7.3 30.5 ± 4.3
   L-SEL-Ab 13.7 ± 2.2 13.6 ± 2.2 11.6 ± 1.8 12.8 ± 2.1 11.9 ± 2.2 12.4 ± 2.0 16.4 ± 2.0 32.7 ± 2.5 39.7 ± 3.4 41.9 ± 6.3 31.6 ± 4.1
ALT (U/l)            
   Placebo 12 ± 3 12 ± 2 9 ± 2 8 ± 2 25 ± 11 46 ± 20 78 ± 27 112 ± 21 93 ± 24 68 ± 12 71 ± 18
   L-SEL-Ab 13 ± 2 10 ± 2 7 ± 0 7 ± 2 13 ± 4 16 ± 5 37 ± 13 93 ± 35 110 ± 28 100 ± 26 100 ± 30
  1. Organ function in baboons infused with live Escherichia coli and treated with either placebo or anti-L-selectin antibody. ap = 0.047.
  2. ALT, alanine transferase; BUN, blood urea nitrogen; L-SEL-Ab, anti-L-selectin antibody; nd, not done.