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Archived Comments for: Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis

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  1. Metabolic effects of tricarboxylic acid cycle intermediates

    Heikki Savolainen, Dept. of Occup. Safety & Hlth, Tampere, Finland

    16 November 2005

    The authors correctly stress the importance of lactate in acidosis but it should be remembered that succinate and fumarate have important metabolic roles as well. Succinate inhibits the prolyl hydroxylation of Hypoxia Inducible Factor -1 (HIF-1) in the proteasome pathway (1) thereby allowing the upregulation of hypoxia responsive elements (HRE). This could complicate the treatment while it also offers therapy options.

    1. Brière et al. Hum Mol Genet 14: 3263-9 (2005)

    Competing interests

    None declared