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Table 2 Concentrations of thrombin used in experiments

From: New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated)

 

Concentration (nM)

Most historical experiments

20–500

EC50 for PAR-1 activation

0.05

Baseline levels of markers of thrombin generation in PROWESS patients (severe sepsis)

~0.1–1

More recent studies of APC's effects on thrombin/PAR-1/endothelial cells

0.02–1

  1. APC, activated protein C; EC50, Concentration inducing half-maximum activation of PAR-1; PAR-1, protease-activated receptor 1; PROWESS, Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
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Critical Care

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