Pulse high-volume haemofiltration for treatment of severe sepsis: effects on hemodynamics and survival

Table 3 Effects of pulse high-volume haemofiltration on haemodynamic variables

Variables	Pre-PHVHF	Mid-PHVHF	End-PHVHF	6 hours after PHVHF	12 hours after PHVHF	P
Noradrenaline Dose (μg/min)	48 (0–114)	40 (0–97)*	40 (0–93)	40 (0–69)*	33 (0–67)**	0.001
SBP (mmHg)	124.32 ± 25.63	126.64 ± 22.10	133.00 ± 24.55	133.06 ± 23.88	133.16 ± 26.15	0.04
MAP (mmHg)	82.16 ± 18.31	85.02 ± 18.82	86.88 ± 17.56	87.76 ± 20.65	87.26 ± 22.05	NS
CI (l/min per m²)	3.4 ± 1.1	3.4 ± 1.2	3.5 ± 1.0	3.5 ± 1.1	3.5 ± 1.2	NS
HR (beats/min)	97.28 ± 25.53	99.62 ± 22.94	100.06 ± 21.79	99.94 ± 20.71	95.62 ± 20.66	0.04
Temperature (°C)	36.7 ± 1.0	36.8 ± 0.8	36.8 ± 0.8	36.9 ± 0.8	36.7 ± 0.9	NS
PaO₂/FiO₂	230.9 ± 109.1	232.8 ± 104.4	243.0 ± 105.6	230.2 ± 109.9	234.6 ± 106.4	NS

Normally distributed values are reported as mean ± standard deviation, and the statistical test used was analysis of variance for repeated measurements. Non-normally distributed values are reported as median (25th to 75th percentile), and P value was determined using Friedman's two-way analysis of varience with post-hoc Wilcoxon signed rank test. *P < 0.05, **P < 0.01 versus baseline. HR, heart rate; CI, cardiac index; MAP, mean arterial pressure; PaO₂/FiO₂, arterial oxygen tension/fractional inspired oxygen; PHVHF, pulse high-volume haemofiltration; SBP, systolic blood pressure.

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