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The effect on renal function in high pulmonary flow infants under hypoxic therapy

Objective

To evaluate the effect on renal function in high pulmonary flow infants under hypoxic therapy.

Patients and methods

The patients were eight infants with heart failure due to high pulmonary flow who needed to use nitrogen before surgical correction. Nitrogen was administered through the oxygen inlet line of a Servo 300® ventilator and FiO2 was kept in the range 0.13–0.18. Creatinine clearance (CCr), CH2O, and FENa were measured daily until the operation.

Results

CCr increased from 30 ± 1.7 ml/min to 42 ± 24 ml/min, while PO2 decreased from 47.4 ± 8.42 mmHg (FiO2 0.21) to 40.0 ± 6.06 mmHg (FiO2 0.16 ± 0.02).

Conclusion

Hypoxic therapy for high pulmonary flow infants improved creatinine clearance as well as pulmonary flow.

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Asakura, A., Miyaji, A., Hayami, H. et al. The effect on renal function in high pulmonary flow infants under hypoxic therapy. Crit Care 9, P352 (2005). https://doi.org/10.1186/cc3415

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Keywords

  • Oxygen
  • Public Health
  • Nitrogen
  • Heart Failure
  • Creatinine