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New presentations about risk factors of ischemic stroke in young persons

The aim of the study was the demonstration of risk factors in young persons who have an acute disorder of the cerebral circulation.

We examined 13 patients aged 42–49 years old and two children (9 and 11 years old) with verified diagnosis of acute disorder of the cerebral circulation by ischemic type during an acute period of the disease. The control group consisted of 10 healthy persons aged 40–50 years old.

Homocysteine, erythropoietin and cytokine concentrations in the blood serum were detected by the immunochemiluminescent analyzer 'IMMULITE' (USA). The values of the lipid metabolism (common cholesterol, different density lipoproteins, triglycerides, B lipoproteins) were detected by the analyzer 'HITACHI-912' (Japan). To determine the rheologic properties of the blood we investigated its viscosity by the rotation viscometer ABR-2 (Russia). Fibrinogen concentration was detected by the coagulograph ACL-100 (Italy). The significant differences between groups were detected by Student and Wilkoxon–Mann–Whitney criteria.

The study resulted in the observation of moderate hyperhomocysteinemia, atherogenic dislipidemia, blood rheologic properties and erythropoesis, pathology, and immune system disorders. Patients with hyperhomocysteinemia did not have common risk factors; their ischemic stroke had pathogenetic features: atherothrombotic subtype, with interrupted step onset and gradual growing of the symptoms during several hours or days with expressed neurological deficit. Examined children had a homocysteine concentration in blood serum of 18.4 ± 10.4 μmol/l, versus 4.66 ± 0.31 μmol/l in healthy children at the compared age. The main risk factor in young persons with ischemic stroke's atherothrombotic subtype is thus an increased level of homocysteine.

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Ustyantseva, I., Vizilo, T., Khokhlova, O. et al. New presentations about risk factors of ischemic stroke in young persons. Crit Care 9, P276 (2005).

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  • Ischemic Stroke
  • Homocysteine
  • Erythropoietin
  • Young Person
  • Hyperhomocysteinemia