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Table 3 Systemic and intestinal CO2-derived parameters in sham, normal and increased blood flow groups

From: Increased blood flow prevents intramucosal acidosis in sheep endotoxemia: a controlled study

Parameter

Group

Basal

Endotoxemia

   

30 min

60 min

90 min

120 min

Mixed venous – arterial PCO2 (mmHg)

Sham

6 ± 2

6 ± 2

6 ± 2

6 ± 2

5 ± 2

 

Normal

7 ± 2

8 ± 2

7 ± 2

8 ± 3

8 ± 3†

 

Increased

6 ± 2

6 ± 3

7 ± 5

7 ± 4

4 ± 1‡

Mesenteric venous – arterial PCO2 (mmHg)

Sham

6 ± 2

5 ± 2

5 ± 2

6 ± 2

5 ± 2

 

Normal

7 ± 2

8 ± 2

8 ± 3

10 ± 4

10 ± 2*†

 

Increased

8 ± 3

6 ± 2

8 ± 4

8 ± 3

6 ± 1*‡

Intramucosal – arterial PCO2 (mmHg)

Sham

4 ± 4

5 ± 8

5 ± 8

5 ± 8

6 ± 9

 

Normal

7 ± 4

6 ± 5

12 ± 5

15 ± 6*‡

19 ± 4*‡

 

Increased

5 ± 7

2 ± 9

7 ± 7

12 ± 8

9 ± 6†

Systemic VCO2 (ml/min per kg)

Sham

5.2 ± 1.9

4.5 ± 1.2

4.0 ± 1.5

4.7 ± 1.2

4.6 ± 1.8

 

Normal

6.0 ± 2.4

4.9 ± 1.4

4.9 ± 1.7

5.0 ± 1.3

5.0 ± 1.7

 

Increased

6.5 ± 2.5

4.8 ± 2.4

6.1 ± 2.8

5.8 ± 2.3

5.8 ± 4.7

Intestinal VCO2 (ml/min per kg)

Sham

36.7 ± 10.9

38.1 ± 11.3

34.0 ± 8.8

43.2 ± 10.6

36.7 ± 5.6

 

Normal

37.7 ± 10.9

35.3 ± 11.6

37.2 ± 13.7

41.8 ± 20.3

36.7 ± 16.2

 

Increased

36.5 ± 21.8

35.3 ± 14.6

27.4 ± 9.4

35.8 ± 12.9

34.0 ± 7.4

Mixed venous blood capacity for transporting CO2 (ml/100 ml per mmHg)

Sham

0.67 ± 0.12

0.59 ± 0.40

0.51 ± 0.11

0.61 ± 0.21

0.61 ± 0.13

 

Normal

0.62 ± 0.12

0.49 ± 0.12*

0.55 ± 0.04*

0.47 ± 0.09*

0.44 ± 0.09*†

 

Increased

0.67 ± 0.24

0.38 ± 0.27*

0.42 ± 0.24*

0.45 ± 0.19*

0.48 ± 0.12*†

Mesenteric venous blood capacity for transporting CO2 (ml/100 ml per mmHg)

Sham

1.14 ± 0.24

1.15 ± 0.32

1.22 ± 0.29

1.37 ± 0.22

1.28 ± 0.08

 

Normal

1.04 ± 0.22

0.99 ± 0.38

0.86 ± 0.24†

0.78 ± 0.33*†

0.76 ± 0.24*†

 

Increased

1.17 ± 0.45

0.85 ± 0.29

0.66 ± 0.27†

0.81 ± 0.19†

0.69 ± 0.18*†

  1. * P < 0.05 versus basal. † P < 0.05 versus sham. ‡ P < 0.05 versus normal. Sham, sham group; normal, normal blood flow group; increased, increased blood flow group.
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