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Table 1 Haemodynamics during acute lung injury in sheep

From: Extravascular lung water assessed by transpulmonary single thermodilution and postmortem gravimetry in sheep

Parameter Group Time point (hours)
   0 1 2 3 4 5 6
PVRI (dyne·s/cm5 per m2) Sham 117 ± 14 131 ± 19 141 ± 10 145 ± 11 114 ± 21 133 ± 13 151 ± 16
  LPS 115 ± 6 284 ± 20* 240 ± 21* 198 ± 31 193 ± 26* 199 ± 23* 182 ± 16*
  OA 103 ± 9 351 ± 64‡§ 300 ± 45‡§ - - - -
GEDVI (ml/m2) Sham 570 ± 46 601 ± 68 572 ± 43 566 ± 12 661 ± 74 607 ± 67 655 ± 60
  LPS 571 ± 23 620 ± 57 564 ± 32 579 ± 42 598 ± 38 624 ± 42 615 ± 37
  OA 646 ± 38 629 ± 60 590 ± 55 - - - -
ITBVI (ml/m2) Sham 764 ± 62 806 ± 91 766 ± 58 759 ± 16 886 ± 99 813 ± 90 878 ± 81
  LPS 765 ± 30 831 ± 76 756 ± 43 776 ± 57 801 ± 51 836 ± 57 825 ± 49
  OA 866 ± 51 912 ± 42 790 ± 74 - - - -
HR (beats/min) Sham 106 ± 6 104 ± 8 96 ± 7 91 ± 5 99 ± 6 98 ± 11 97 ± 5
  LPS 96 ± 4 122 ± 6 109 ± 6 109 ± 4* 109 ± 8 122 ± 4* 130 ± 5*
  OA 111 ± 5 104 ± 13 102 ± 13 - - - -
CI (l/min per m2) Sham 5.7 ± 0.3 5.5 ± 0.3 5.2 ± 0.3 5.1 ± 0.2 5.4 ± 0.4 5.2 ± 0.3 5.3 ± 0.3
  LPS 5.7 ± 0.1 7.3 ± 0.5*†ll 5.9 ± 0.2 5.8 ± 0.3 5.6 ± 0.4 6.2 ± 0.3* 6.8 ± 0.2*
  OA 6.1 ± 0.3 4.5 ± 0.3§ 4.6 ± 0.5 - - - -
MAP (mmHg) Sham 102 ± 5 101 ± 6 101 ± 6 101 ± 5 102 ± 5 102 ± 5 101 ± 4
  LPS 94 ± 4 104 ± 5 105 ± 3 106 ± 4 105 ± 3 104 ± 5 100 ± 6
  OA 94 ± 4 101 ± 2 104 ± 4§ - - - -
SVRI (dyne·s/cm5 per m2) Sham 1453 ± 101 1496 ± 125 1589 ± 138 1536 ± 105 1579 ± 109 1607 ± 119 1681 ± 169
  LPS 1410 ± 81 1128 ± 102 1352 ± 62 1515 ± 107 1428 ± 101 1308 ± 79 1126 ± 58*
  OA 1266 ± 63 1847 ± 368 1670 ± 147§ - - - -
  1. Data are expressed as mean ± standard error of the mean. *P < 0.05, LPS versus sham-operated group; P < 0.05, versus t = 0 hours in LPS group; P < 0.05, OA versus sham-operated group; §P < 0.05, versus t = 0 hours in OA group; llP < 0.05, LPS versus OA group. CI, cardiac index; GEDVI, global end-diastolic volume index; HR, heart rate; ITBVI, intrathoracic blood volume index; LPS, lipopolysaccharide; MAP, mean arterial pressure; OA, oleic acid; PVRI, pulmonary vascular resistance index; Sham, sham-operated; SVRI, systemic vascular resistance index.