Table 1 Haemodynamics during acute lung injury in sheep
Parameter | Group | Time point (hours) | ||||||
|---|---|---|---|---|---|---|---|---|
0 | 1 | 2 | 3 | 4 | 5 | 6 | ||
PVRI (dyne·s/cm5 per m2) | Sham | 117 ± 14 | 131 ± 19 | 141 ± 10 | 145 ± 11 | 114 ± 21 | 133 ± 13 | 151 ± 16 |
LPS | 115 ± 6 | 284 ± 20*† | 240 ± 21*† | 198 ± 31† | 193 ± 26*† | 199 ± 23*† | 182 ± 16*† | |
OA | 103 ± 9 | 351 ± 64‡§ | 300 ± 45‡§ | - | - | - | - | |
GEDVI (ml/m2) | Sham | 570 ± 46 | 601 ± 68 | 572 ± 43 | 566 ± 12 | 661 ± 74 | 607 ± 67 | 655 ± 60 |
LPS | 571 ± 23 | 620 ± 57 | 564 ± 32 | 579 ± 42 | 598 ± 38 | 624 ± 42 | 615 ± 37 | |
OA | 646 ± 38 | 629 ± 60 | 590 ± 55 | - | - | - | - | |
ITBVI (ml/m2) | Sham | 764 ± 62 | 806 ± 91 | 766 ± 58 | 759 ± 16 | 886 ± 99 | 813 ± 90 | 878 ± 81 |
LPS | 765 ± 30 | 831 ± 76 | 756 ± 43 | 776 ± 57 | 801 ± 51 | 836 ± 57 | 825 ± 49 | |
OA | 866 ± 51 | 912 ± 42 | 790 ± 74 | - | - | - | - | |
HR (beats/min) | Sham | 106 ± 6 | 104 ± 8 | 96 ± 7 | 91 ± 5 | 99 ± 6 | 98 ± 11 | 97 ± 5 |
LPS | 96 ± 4 | 122 ± 6† | 109 ± 6 | 109 ± 4*† | 109 ± 8 | 122 ± 4*† | 130 ± 5*† | |
OA | 111 ± 5 | 104 ± 13 | 102 ± 13 | - | - | - | - | |
CI (l/min per m2) | Sham | 5.7 ± 0.3 | 5.5 ± 0.3 | 5.2 ± 0.3 | 5.1 ± 0.2 | 5.4 ± 0.4 | 5.2 ± 0.3 | 5.3 ± 0.3 |
LPS | 5.7 ± 0.1 | 7.3 ± 0.5*†ll | 5.9 ± 0.2 | 5.8 ± 0.3 | 5.6 ± 0.4 | 6.2 ± 0.3* | 6.8 ± 0.2*† | |
OA | 6.1 ± 0.3 | 4.5 ± 0.3§ | 4.6 ± 0.5 | - | - | - | - | |
MAP (mmHg) | Sham | 102 ± 5 | 101 ± 6 | 101 ± 6 | 101 ± 5 | 102 ± 5 | 102 ± 5 | 101 ± 4 |
LPS | 94 ± 4 | 104 ± 5† | 105 ± 3† | 106 ± 4† | 105 ± 3† | 104 ± 5 | 100 ± 6 | |
OA | 94 ± 4 | 101 ± 2 | 104 ± 4§ | - | - | - | - | |
SVRI (dyne·s/cm5 per m2) | Sham | 1453 ± 101 | 1496 ± 125 | 1589 ± 138 | 1536 ± 105 | 1579 ± 109 | 1607 ± 119 | 1681 ± 169 |
LPS | 1410 ± 81 | 1128 ± 102† | 1352 ± 62 | 1515 ± 107 | 1428 ± 101 | 1308 ± 79 | 1126 ± 58*† | |
OA | 1266 ± 63 | 1847 ± 368 | 1670 ± 147§ | - | - | - | - | |