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Table 3 Summary of studies of dantrolene pretreatment of heat stroke in animals

From: Clinical review: Treatment of heat stroke: should dantrolene be considered?

    Numbers included    
Reference Study type Model Dantrolene treatment arms Control arms Dantrolene dose (mg/kg bw) Improved parameters Nonimproved parameters
[20] Randomized controlled Exercising sheep 6 6 1.5–3 Body temperature, Severity of heat stroke signs, changes in serum enzymes and hormones, survivala -
[18] Randomized controlled Exercising rats 7 7 140 - Physical capacity
   Nonexercising rats 7 7 140 Endurance in the heat -
  1. aTrend only. bw, Body weight.