Table 3 Summary of studies of dantrolene pretreatment of heat stroke in animals
From: Clinical review: Treatment of heat stroke: should dantrolene be considered?
| Â | Â | Â | Numbers included | Â | Â | Â | |
|---|---|---|---|---|---|---|---|
Reference | Study type | Model | Dantrolene treatment arms | Control arms | Dantrolene dose (mg/kg bw) | Improved parameters | Nonimproved parameters |
[20] | Randomized controlled | Exercising sheep | 6 | 6 | 1.5–3 | Body temperature, Severity of heat stroke signs, changes in serum enzymes and hormones, survivala | - |
[18] | Randomized controlled | Exercising rats | 7 | 7 | 140 | - | Physical capacity |
| Â | Â | Nonexercising rats | 7 | 7 | 140 | Endurance in the heat | - |