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Table 7 Cerebral haemodynamics

From: Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308]

Parameter Remifentanil (n = 20) Fentanyl (n = 10) Morphine (n = 12)
ICP    
   Mean baseline, mmHg (SD) 11.7 (6.3) (n = 16) 10.8 (8.1) (n = 8) 16.7 (9.0) (n = 10)
   LS mean, mmHg 11.97 13.93 10.31
   LS mean differences   1.95 -1.66
   95% CI   -1.70, 5.60 -5.22, 1.90
   Pa   0.285 0.351
CPP    
   Mean baseline, mmHg (SD) 80.5 (9.1) (n = 12) 85.5 (15.8) (n = 5) 73.6 (17.6) (n = 8)
   LS mean, mmHg 68.77 75.58 76.99
   LS mean differences   6.81 8.22
   95% CI   -8.13, 21.74 -5.29, 21.72
   Pa   0.359 0.223
  1. CI, confidence interval; CPP, cerebral perfusion pressure; ICP, intra-cranial pressure; LS, least square; SD, standard deviation. aRemifentanil versus fentanyl/morphine, adjusting for baseline.