Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308]

Table 7 Cerebral haemodynamics

Parameter	Remifentanil (n = 20)	Fentanyl (n = 10)	Morphine (n = 12)
ICP
Mean baseline, mmHg (SD)	11.7 (6.3) (n = 16)	10.8 (8.1) (n = 8)	16.7 (9.0) (n = 10)
LS mean, mmHg	11.97	13.93	10.31
LS mean differences		1.95	-1.66
95% CI		-1.70, 5.60	-5.22, 1.90
P^a		0.285	0.351
CPP
Mean baseline, mmHg (SD)	80.5 (9.1) (n = 12)	85.5 (15.8) (n = 5)	73.6 (17.6) (n = 8)
LS mean, mmHg	68.77	75.58	76.99
LS mean differences		6.81	8.22
95% CI		-8.13, 21.74	-5.29, 21.72
P^a		0.359	0.223

CI, confidence interval; CPP, cerebral perfusion pressure; ICP, intra-cranial pressure; LS, least square; SD, standard deviation. ^aRemifentanil versus fentanyl/morphine, adjusting for baseline.

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