Figure 3

(a) Transpulmonary pressure gradient in the candesartan group. Mean pulmonary artery pressure (Ppa) minus occluded Ppa (Ppao) at constant cardiac output in six dogs as the fractional inspired oxygen (FiO₂) was decreased from 0.4 to 0.1, before (base) and after administration of candesartan. (b) Hypoxic response in the candesartan group. Hypoxic response defined as the increase in the gradient between Ppa and Ppao measured at constant cardiac output in response to a reduction in FiO₂ from 0.4 to 0.1 at baseline (base) and after administration of candesartan in six dogs. In both panels the vertical bars indicate the standard error of the mean.