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Effects of urinary trypsin inhibitor for trauma patients

We investigated the effect of urinary trypsin inhibitor (UTI) on the output of plasma mean neutrophil elastase (PMNE) and cytokine.

The participants of this study are 15 trauma patients with shock on arrival at our insutitution. We divide them in two groups: one group is administrated 300,000 U (intravenous) UTI, and the other is the control group. At 0, 1, 3, 5, and 7 days after hospitalization of each group, we measured the serum levels of IL-6, IL-8, UTI, PMNE, thrombomodulin, protein C, and the SIRS score and SOFA score as an index of severity.

The PMNE levels in the UTI-administered group were observed to be significantly lower than those in the control group at 1 and 3 days after hospitalization.

These data suggest that. UTI can suppress vascular endothelial cell disorders by inhibiting the production of PMNE and by direct inhibition of PMNE.

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Deguchi, Y., Soga, Y., Suga, H. et al. Effects of urinary trypsin inhibitor for trauma patients. Crit Care 8 (Suppl 1), P200 (2004).

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