Gastric tonometry in patients recovering from paracetamol overdose
© Current Science Ltd 1998
Published: 1 March 1998
To investigate the relationship between gastric intra-mucosal pH and recovery from paracetamol overdose.
Patients admitted to the liver intensive care unit, not fulfilling transplantation criteria, were prospectively enrolled. A gastrointestinal tonometer was placed into the stomach and the intramucosal pH was calculated every day until 10 days post overdose, by an intermittent saline bolus technique.
Gastric intramucosal pH significantly falls in the recovery phase of paracetamol overdose and this is not related to outcome. This may represent diversion of blood away from the portal system to the regenerating liver.