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  • Meeting abstract
  • Open Access

Variations of veno-arterial and mucosal-arterial CO2 gap during continuous veno-venous hemodiafiltration

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Critical Care19982 (Suppl 1) :P133

  • Published:


  • Oxygen
  • Public Health
  • Emergency Medicine
  • Continuous Measure
  • Hemodynamic Change


Veno-arterial CO2 gap (P(v-a) CO2) and mucosal-arterial CO2) gap (P(g-a) CO2 may help to detect tissular dysoxia. Continuous veno-venous hemodiafiltration (CVVHD) technics are well tolerated in septics patients.


Change of P(v-a) CO2 and of P(g-a) CO2 during CVVHD.


Prospective study. Intubated and ventilated patients. Hemodynamics and systemic oxygen derived parameters were collected before and during CVVHD (H0-H6). CVVHD setting parameters (PRISMA®, HOSPAL) were standardised. Gastric mucosal PCO2 continously monitored (NGS (TONOMETRICS) and TONOCAP® (DATEX). P(v-a) CO2 and P(g-a) CO2 calculated. Continuous measure of end tidal CO2 (PetCO2). Statistics: ANOVA, Scheffe t test for paired and unpaired values


7 patients (71.7 ± 5 years, SAPS II = 59.5 ± 3.7) included. PetCO2 and P(v-a)CO2 did not change from H0 to H6. P (g-a)CO2 increased significantly at H1 (*P < 0.05) then progressively decrease but did not reach the initial value.



The marked increase of P(g-a)CO2 during CVVHD could be explained by acid-base status in the mucosa independent of hemodynamics changes.

Authors’ Affiliations

Réa, Médicale, C. Hospitalier, 59322 Valenciennes Cedes, France


© Current Science Ltd 1998