- Poster presentation
- Open Access
Correlation between LiMON®-derived liver function parameters and classic liver function tests, intra-abdominal pressure (IAP) and organ failure in mixed ICU patients
© BioMed Central Ltd. 2004
- Published: 15 March 2004
- Organ Failure
- Gammaglutamyl Transferase
Indocyaninegreen (ICG) clearance can be measured with the LiMON® device (Pulsion, Germany) and is expressed by the plasma disappearance rate (PDR) for ICG (normal value 18–25%) and the residual ICG after 15 min (R15, normal value 0–10%). In this study we investigated the correlation between PDR/R15 and IAP, SOFA score, and classic liver function tests in mixed ICU patients.
A total of 130 paired measurements were performed in 28 patients. The IAP was obtained using a balloon-tipped stomach catheter connected to an IAP monitor (Spiegelberg, Germany). The male/female ratio was 3/2, age was 58.2 ± 12.1 years, APACHE II score was 25.8 ± 15.7, SAPS II score was 44.4 ± 13.9, MODS was 6.4 ± 3, and SOFA score was 6.9 ± 3.6. The number of measurements in each patient was 4.6 ± 3.6. Calculation of correlation was performed with the Prism GraphPad™ software (version 2.00, 31 October 1995), and values are presented as mean ± SD.
The values for IAP were 10 ± 4 mmHg (normal value 0–5 mmHg), PDR was 13.6 ± 8.4%, and R15 was 22.3 ± 19.8%. The correlation between IAP and PDR/R15 was poor although significant (R = 0.4), as was the correlation between PDR/R15 and the classic liver test (with R < 0.1): aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, gammaglutamyl transferase, alkaline phosphatase, or venous NH3. From the so- called liver synthesis function tests, albumin, bilirubin, plasma cholinesterase levels and prothrombin time, only the latter had a good correlation. Neither platelets nor general hemodynamic parameters or lactate were well correlated. A significant and reasonable correlation was observed between PDR/R15 and SOFA score and the number of organ failures. Finally, the correlation between PDR and R15 was good (R = 0.8). Mortality was 57%, PDR was significantly lower (10.4 ± 5.7 vs 16.3 ± 6.6) in patients who died, while IAP (10.6 ± 3.9 vs 8.6 ± 3.6), SOFA score (13 ± 3.3 vs 7.7 ± 3.4) and number of organ failures (2.5 ± 1.1 vs 1.2 ± 0.9) were significantly higher. The number of measurement failures was 14% before and 3% after the software upgrade.