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Correlations between plasma concentration of N-terminal pro-brain natriuretic peptide and cardiac function in patients with cardiovascular diseases

Objective

To demonstrate the relations of the plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentration with the severity of heart failure, the underling heart disease and New York Heart Association (NYHA) functional classifications in patients with cardiovascular disease.

Method

Plasma NT-ProBNP concentrations of patients with cardiovascular disease (n = 65) and of normal controls (n = 16) were measured by nonextracted, enzyme-linked, sandwich immunoassay (Elecsys®) after admission. Constructive and functional parameters of heart were measured with echocardiography in 65 patients at the same time.

Result

The plasma NT-ProBNP concentrations of patients were significantly higher than those of normal controls. They also increased according to the severity of heart failure classified by NYHA functional classifications (P < 0.001). The plasma NT-ProBNP concentrations and left ventricular end diastolic volume (LVEDV) also had significant positive correlations with NYHA functional classifications (r = 0.769, P < 0.001 and r = 0.376, P = 0.02, respectively). For NT-proBNP in the diagnosis of heart failure, a level > 200 pg/ml had a sensitivity of 100%, a specificity of 97%, a positive predictive value of 98% and a negative predictive value of 100%.

Conclusion

The plasma levels of NT-ProBNP increase significantly according to the severity of heart failure classified by NYHA functional classifications. The plasma NT-ProBNP concentration is a sensitive biochemical parameter for evaluating the heart function.

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Zhao, Y., Tian, Y., Gao, W. et al. Correlations between plasma concentration of N-terminal pro-brain natriuretic peptide and cardiac function in patients with cardiovascular diseases. Crit Care 8, P56 (2004). https://doi.org/10.1186/cc2523

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Keywords

  • Heart Failure
  • Cardiovascular Disease
  • Normal Control
  • Cardiac Function
  • Significant Positive Correlation