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  • Meeting abstract
  • Open Access

Polimixin B use in treatment of multidrug-resistant Pseudomonas aeruginosa infection

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Critical Care20037 (Suppl 3) :P68

https://doi.org/10.1186/cc2264

  • Published:

Keywords

  • Intensive Care Unit
  • Urinary Tract
  • Tract Infection
  • Respiratory Tract
  • Urinary Tract Infection

Objective

To describe the use of polimixin B as treatment of multidrug-resistant (MDR) Pseudomonas aeruginosa infection.

Method

In this retrospective study we describe the features and demographic data of 27 patients with MDR P. aeruginosa treated with polimixin B, admitted to a private hospital medical and surgical intensive care unit (ICU).

Results

Twenty-three patients (85.2%) were infected with MDR P. aeruginosa, confirmed with cultures and resistance tests, during the ICU stay. In greater part, they were isolated from respiratory and urinary tract infections (33.3% and 25.9%, respectively). Four patients were treated empirically, with 50% of therapy response. The study group presented a mean age of 63 years, 51.9% males, with a mean Acute Physiology and Chronic Health Evaluation II score of 24.63. Sixty-three percent of our patients were first admitted to the hospital with community-acquired infection, none caused by P. aeruginosa. The most frequent cause for ICU admission was communitarian or nosocomial respiratory tract infection (29.9%). The mean time of polimixin B use was 15.59 days. Twelve patients (44%) used imipinem, 12 patients (44%) used teicoplanin and three patients (11%) used vancomicin, for more than 3 days, during the ICU stay before polimixin B use. After treatment with polimixin B, we had 40.7% response and improvement and 59.3% death.

Conclusion

After this series, we suggest that polimixin B can be a useful alternative for treatment of MDR P. aeruginosa infection.

Authors’ Affiliations

(1)
SSA, BA, Hospital Português Study and Research Center, Hospital Português, Salvador, Bahia, Brazil

References

  1. Sader HS, et al.: Epidemiologic typing of multiply drug-resistant Pseudomonas aeruginosa isolated from an outbreak in an intensive care unit. Diagn Microbiol Infect Dis 1993, 17: 13-18. 10.1016/0732-8893(93)90063-DView ArticlePubMedGoogle Scholar
  2. Bukholm G, et al.: An outbreak of multidrug-resistant Pseudomonas aeruginosa associated with increased risk of patient death in an intensive care unit. Infect Control Hosp Epidemiol 2002, 23: 441-446.View ArticlePubMedGoogle Scholar
  3. Bertrand X, et al.: Pseudomonas aeruginosa : antibiotic susceptibility and genotypic characterization of strains isolated in the intensive care unit. Clin Microbiol Infect 2001, 7: 706-708. 10.1046/j.1198-743x.2001.00345.xView ArticlePubMedGoogle Scholar

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