Volume 2 Supplement 1

18th International Symposium on Critical Care and Emergency Medicine: Poster abstracts

Open Access

Treatment of postoperative lung injury in patients with SIRS by methylprednisolone

  • M Sumida1,
  • T Fukada1,
  • Y Tsukazaki1,
  • N Kobayashi1,
  • Y Mukubou1,
  • T Sumida2,
  • K Taira1 and
  • M Kawamata1
Critical Care19982(Suppl 1):P094


Published: 1 March 1998


Intraperitoneal hyperthermic perfusion (IPHP) is performed clinically as one treatment for cancer patients with advanced gastrointestinal cancer. All patients are fallen the systemic inflammatory response syndrome (SIRS) by IPHP. In our previous work, we clarified the elevated TNF-α in the serum of IPHP patients [1]. Glucocorticoids are well known inhibitors of TNF-α [2]. We examined serum TNF-α levels before and after administration of methylprednisolone (MPS) and compaired the lung injury score in postoperative days between the group of MPS and control.


Seventeen patients with gastrointestinal cancer were undergone surgery combined with IPHP. Group 1 (10 patients): MPS was not adminstrated. Group 2 (7 patients): MPS was administered before and during IPHP. We measured serum TNF-α levels and evaluate the metabolism, hematorogy, hemodynamics and the post-operative lung injury.


In group 1, serum TNF-α levels was increased to 46.0 ± 25.7 pg/ml (mean ± SD) at the end of IPHP and patients were SIRS with the postoperative lung injury. In group 2, TNF-α was not detected but postoperative lung injury were improved.


MPS inhibited the production of TNF-α which was able to improve postoperative lung injury. Pre-emptive MPS might be one of strategy for treatment of lung injury during SIRS.

Authors’ Affiliations

Department of Anesthesiology, Tokyo Women's Medical College
Department of Anesthesiology, Tokyo Women's Medical CollegeInstitute of Medical ScienceSt Marianna University School of Medicine


© Current Science Ltd 1998