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Acute, normovolemic hemodilution: effects on systemic and splanchnic blood flows and oxygen metabolism
Critical Care volume 7, Article number: P31 (2003)
The impact of acute normovolemic hemodilution (HD) on splanchnic perfusion was evaluated in 21 anesthetized (fentanyl and vancuronium) mongrel dogs (16 ± 1 kg). They were randomized to controls (n = 7, no HD), moderate HD (hematocrit 25 ± 3%, n = 7) or severe HD (hematocrit 15 ± 3% ml/kg), through an isovolemic exchange of whole blood and 6% hydroxyethylstarch at a 20 ml/min rate, to the target hematocrit. The animals were followed 120 min after HD. Cardiac output (ml/min), portal vein blood flow (ml/min), portal vein-arterial CO2 gradient (mmHg) and PCO2 gap (gas tonometry, mmHg), and splanchnic perfusion were evaluated through portal vein blood flow and gas tonometry.
Exchange blood volumes were 33.9 ± 3.3 and 61.5 ± 5.8 ml/kg for moderate HD and severe HD, respectively. Controls maintained a hematocrit of around 41% throughout the study. Arterial pressure remained stable for all animals.
Global and regional hemodynamic stability were maintained after moderate and severe HD. However, a moderate gastric mucosal acidosis was induced with a hematocrit of 15%, which may become relevant after major surgery or trauma.
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Perin, D., Poli de Figueiredo, L., Cruz, E. et al. Acute, normovolemic hemodilution: effects on systemic and splanchnic blood flows and oxygen metabolism. Crit Care 7, P31 (2003). https://doi.org/10.1186/cc2227
- Cardiac Output
- Hemodynamic Stability
- Exchange Blood