Table 2 Summary of causes of death in placebo-controlled clinical trials1
Drotrecogin alfa (activated; n [%]) | Placebo (n [%]) | |
|---|---|---|
Cause of death category | ||
Sepsis-induced multiorgan failure | 113 (47.9) | 107 (39.2) |
Refractory septic shock | 49 (20.8) | 65 (23.8) |
Respiratory failure | 32 (13.6) | 51 (18.7) |
Myocardial infarction | 9 (3.8) | 11 (4.0) |
Primary cardiac arrhythmia | 6 (2.5) | 9 (3.3) |
Hemorrhage | 4 (1.7) | 1 (0.4) |
Intracranial hemorrhage | 2 (0.8) | 1 (0.4) |
Stroke | 2 (0.8) | 7 (2.6) |
Other | 19 (8.1) | 21 (7.7) |
Total deaths | 236 (100) | 273 (100) |