Case report: Severe mercuric sulphate poisoning treated with 2,3-dimercaptopropane-1-sulphonate and haemodiafiltration

Table 1 Pharmacokinetic parameter estimates and precentage coefficients of variation obtained from the blood concentration–time data

		Estimated parameters						Derived parameters (assuming an ingested dose of 1000 mg mercuric sulphate) ingested dose of 1000 mg mercuric sulphate)
Data set		C₁^a (μg/l)	λ ₁^a (/h)	C₂^a (μg/l)	λ ₂^a (/h)	C₃^a (μg/l)	λ ₃^a (/h)	Clearance (l/h)	Vss^b x(l)	λ₁ t1/2^c (h)	λ₂ t1/2^c (h)	λ₃ t1/2^d (h)
All data	Parameter estimate	15.2	0.105	3.18	0.0121	0.273	0.0016	1.74	381	6.60	57.2	425
	% cve^e	25	28	14	15	47	51.3	9.14	37.5	28.5	15.3	51.2
Data minus first point	Parameter estimate			3.66	0.0139	0.318	0.0019	2.33	572		50.0	362
	% cv^e			10.2	10.7	32.3	32.4	4.98	23.1		10.6	32.3

^a Concentration at t hours after dose (see Eqn 1 in text); C₁, C₂ and C₃ are the coefficients associated with the i^th exponent and λ₁, λ₂ and λ₃ represent the distribution and elimination rate constants. ^bVss is the volume of distribution at steady state. ^cDistribution half-lives. ^dElimination half-life. ^ePercentage coefficient of variation of the parameter estimate.

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