Continuous infusion of propofol for sedation of pediatric patients following open-heart surgery
© Current Science Ltd 1998
Published: 1 March 1998
The aim of this study was to prospectively evaluate safety and efficacy of propofol infusion as an alternative sedative agent in children with open-heart surgery.
Twenty-nine pediatric patients with complex congenital lesions, aged between 4 and 48 months, who underwent open-heart surgery, received propofol infusion as sedation after midazolam infusion was ineffective. The effective sedative dose of propofol was between 1.5 and 7.0 mg/kg per h (median 3 mg/kg per h). Measurement of heart rate (HR) electrocardiogram (ECG), blood pressure (BP), arterial blood gas (ABG) including pH, bicarbonate (HCO3), partial carbon dioxide pressure (PCO2), and blood oxygen saturation (PO2); and blood chemistry including liver function tests (LFTs), triglycerides (TG), and total bilirubin (TB), were all done prior to and during propofol therapy.
After 10–288 h of propofol infusion (median 74 h), no statistically significant differences were found in the parameters measured except a decrease in median HR with attendant decrease in BP, and an increase in median TG.
Change in median values