- Meeting abstract
Clinical outcome in ICU patients with Enterobacter bacteremia
Critical Care volume 6, Article number: P83 (2002)
Purpose and methods
To investigate the clinical impact of Enterobacter bacteremia in ICU patients, a retrospective (January 1992–December 2000), matched cohort study was performed. All ICU patients with Enterobacter bacteremia were defined as cases (n = 67). Matching of the controls (1:2–ratio) (n = 134) was based on the APACHE II system: an equal APACHE II score (± 1 point) and admission diagnosis.
There was a high rate of appropriate antibiotic therapy in patients with Enterobacter bacteremia (96%). The mean delay in the start of antibiotic therapy was short (0.5 ± 0.9 days). Following the matching procedure cases and controls had nearly equal APACHE II scores (23 ± 8.3 vs 23 ± 8.3; P = 0.890) and related expected mortality rates (41 ± 24.1% vs 40 ± 24.1%; P = 0.805). Patients with Enterobacter bacteremia had more hemodynamic instability (78% vs 60%; P = 0.015). They also had a longer ICU stay (36 ± 32.1 vs 15 ± 18.7 days; P < 0.001) and a longer ventilator dependence (32 ± 26.8 vs 12 ± 17.0 days; P < 0.001). There was no difference between cases and controls in age (52 ± 19.8 vs 53 ± 19.3 years; P = 0.831), acute respiratory failure (93% vs 84%; P = 0.079) and acute renal failure (16.4% vs 15.8%; P = 0.892). Hospital mortality was not different between cases and control patients (34.3% vs 38.8%; P = 0.536). A multivariate survival analysis showed the APACHE II related expected mortality as the only independent predictor of mortality (HR, 3.7; 95% CI, 2.0–6.7; P < 0.001).
After accurate adjustment for severity of underlying disease and acute illness, no difference in mortality was found between ICU patients with Enterobacter bacteremia (34.3%) and their matched cohort subjects (38.8%). In the presence of accurate and prompt antibiotic therapy, bacteremia involving Enterobacter species does not adversely affect the outcome in ICU patients.
About this article
Cite this article
Blot, S., Vandewoude, K. & Colardyn, F. Clinical outcome in ICU patients with Enterobacter bacteremia. Crit Care 6, P83 (2002). https://doi.org/10.1186/cc1787
- Antibiotic Therapy
- Respiratory Failure
- Acute Respiratory Failure
- Admission Diagnosis
- Matched Cohort