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Treatment of hypercoagulation state in acute myocardial infarction

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It is known that thrombolysis does not always prevent the development of early repeated thrombosis of coronary vessels. We have developed a method of extracorporeal thermal plasmamodification — thermoplasmasorbtion (TPS), which allows to reach significant decrease of its coagulation state (complete removal of fibrinogen, reduction of activity of the external and internal coagulation factors) and decrease of blood viscosity. Is shown, that reinfusion of modificated plasma reduces platelet and red blood cells aggregation. 40 patients with myocardial infarction in acute period underwent the analysis. The TPS was applied to 20 patients (group 1) and 20 underwent conservative treatment (group 2). During clinical supervision more expressive positive dynamics changes were noted in all the patients of group 1: stenocardic cupping already in the 1st day of treatment, hemodynamic stabilization, absence of thrombotic and other complications. The improvement of clinical state of the patients of this group was proved by system and central hemodynamic rate: increase of end diastolic volume, decrease of systole frequencies, increase of ejection fraction with stable head ejection. In our opinion the given changes testify to the improvement of heart work with inclusion of a rate thermal plasmosorbtion in complex treatment of acute myocardial infarction.

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Kreines, V., Sharovarnikov, S., Kravchenko, A. et al. Treatment of hypercoagulation state in acute myocardial infarction. Crit Care 2 (Suppl 1), P048 (1998).

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