Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Volume 6 Supplement 1

22nd International Symposium on Intensive Care and Emergency Medicine

Arterio- and veno-venosus hemofiltration in the treatment of sepsis and septic shock

Critical Care volume 6, Article number: P135 (2002) Cite this article

Many inflammatory agents are known to be released in huge quantities in septic shock. The level of the agents could be decreased by the continuous arterio-, and veno-venosus hemofiltration (CAVH and CVVH).

Our study was conducted to remove the inflammatory mediators from the circulation by the assistance of the CAVH and the control of the hemodynamic stability.

Method

Forty-eight patients was applied on the study. The hemodynamic parameters were measured with the thermodilution technique. The mean arterial pressure (MAP), the pulse (F), the cardiac output (CO), the pulmonary wedge pressure (PCWP), the systemic vascular resistance (SVR), the left and right ventricule work-index (LVSWI, RVSWI) were measured, The oxygen delivery and consumption (DO2, VO2), the serum lactate level were estimated. The inflammatory parameters - C-reactive protein, procalcitonin, white blood cell - were controlled daily. The laboratory tests of fluid balance and inonogram (Na, K in the urine), the clinical signs (temperature, consciousness, APACHE II score) were assessed daily.

Results

The hemodynamic parameters were stable: CO: 9.6-7.8 l/min, SVR: 541-789 dyns cm-5, the tissue oxygenation was improved (DO2 7.5-16.7 ml/min/kg, VO2 1.24-3.4 ml/min/kg). The temperature of patients were decreased (39.2-37.4°C), the urine increased (22.4-43.5 ml/kg/die), the APACHE II score decreased (28.4-19.7) and the GCS (7.8-11.4) increased. The inflammatory parameters were on the normal level after 2 days of the CAVH (CRP: 261-61. PCT: 10-0.5 ng/ml).

The hemodynamic effect of the CAVH or CVVH was favourable, the heart function was improved, the fluid-, and ion-balance could have been controlled well.

References

  1. 1.

    Bellomo R: Blood Purif 1995, 13: 246.

  2. 2.

    Bellomo R, et al.: Continous renal replacement therapy. Int J Intensive Care 2000, 7: 22.

  3. 3.

    Rogiers P: Hemofiltration treatment for sepsis. Is it time for control trial? Kidney IntSuppl 1999, 72: S99.

Download references

Author information

Affiliations

  1. Nephrologic Department, Intensive Care Unit, Bajcsy-Zsilinszky Hospital, Maglodi ut 89-91, Budapest, 1106, Hungary
    • Zs Marjanek
    •  & M Faludi
Authors
  1. Search for Zs Marjanek in:
  2. Search for M Faludi in:

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Marjanek, Z., Faludi, M. Arterio- and veno-venosus hemofiltration in the treatment of sepsis and septic shock. Crit Care 6, P135 (2002). https://doi.org/10.1186/cc1591

Download citation

Keywords

  • Cardiac Output
  • Septic Shock
  • Mean Arterial Pressure
  • Fluid Balance
  • Lactate Level

Critical Care

ISSN: 1364-8535