Volume 2 Supplement 1

18th International Symposium on Intensive Care and Emergency Medicine

Open Access

Nitric oxide (NO) metabolite levels are not increased during hypotensive periods in human sepsis

  • DH Jenkins1, 3,
  • HL Frankel1, 3,
  • AK May1,
  • H Nguyen2,
  • K Simo1,
  • CW Schwab1 and
  • S Bina4
Critical Care19982(Suppl 1):P029

https://doi.org/10.1186/cc159

Published: 1 March 1998

Purpose

Excess NO production has been proposed to cause the hemodynamic derangements of septic shock. This study was undertaken to determine whether serum NO metabolite levels correlate with hemodynamic changes in human sepsis.

Methods

A 12-month prospective study of surgical ICU patients with SIRS, sepsis, severe sepsis or septic shock was undertaken. Serum NO2/NO3 levels were determined by chemiluminescence from blood drawn during blood culture acquisition or hypotension (SBP <90 mmHg), then daily for 7 days or until ICU discharge or death. The following were collected: vital signs, pulmonary artery catheter data, white blood cell count (WBC) and arterial base deficit (BD). T-test analysis compared NO2/NO3 levels in hypotensive and normotensive patients. Pearson correlation coefficients were determined for NO2/NO3 and the variables above. Data are mean ± SEM; P < 0.05 defined significance.

Results

NO2/NO3 levels were 12.2 ± 3.8 pmol/μl in 13 hypotensive vs 12.7 ± 2.0 in 9 normotensive patients (NS). Correlation coefficients (r2) are depicted:

Conclusions

NO metabolite levels are not different in hypotensive and normotensive septic patients. There is poor correlation between NO metabolite levels and physiologic changes in human sepsis. Further study regarding the role of NO as the principal vasodilator in sepsis is warranted.

Table (abstract P029)

 

SBP

P

CI

SVO2

SVR

WBC

BD

NO2/NO3

0.04

0.01

0.10

0.16

0.05

0.09

0.04

Authors’ Affiliations

(1)
Department of Surgery, University of Pennsylvania Medical Center
(2)
National Naval Medical Center, Uniformed Services University of the Health Sciences
(3)
Departments of Surgery, Uniformed Services University of the Health Sciences
(4)
Anesthesiology of the Uniformed Services University of the Health Sciences

Copyright

© Current Science Ltd 1998

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