Nitric oxide (NO) metabolite levels are not increased during hypotensive periods in human sepsis
© Current Science Ltd 1998
Published: 1 March 1998
Excess NO production has been proposed to cause the hemodynamic derangements of septic shock. This study was undertaken to determine whether serum NO metabolite levels correlate with hemodynamic changes in human sepsis.
A 12-month prospective study of surgical ICU patients with SIRS, sepsis, severe sepsis or septic shock was undertaken. Serum NO2/NO3 levels were determined by chemiluminescence from blood drawn during blood culture acquisition or hypotension (SBP <90 mmHg), then daily for 7 days or until ICU discharge or death. The following were collected: vital signs, pulmonary artery catheter data, white blood cell count (WBC) and arterial base deficit (BD). T-test analysis compared NO2/NO3 levels in hypotensive and normotensive patients. Pearson correlation coefficients were determined for NO2/NO3 and the variables above. Data are mean ± SEM; P < 0.05 defined significance.
NO2/NO3 levels were 12.2 ± 3.8 pmol/μl in 13 hypotensive vs 12.7 ± 2.0 in 9 normotensive patients (NS). Correlation coefficients (r2) are depicted:
Table (abstract P029)