Skip to main content

Table 4 Mean changes between baseline and 90 days for the attributes of survivors in the KyberSept trial: patients in hospital at 90 days and all-survivors

From: Quality of life effects of antithrombin III in sepsis survivors: results from the KyberSept trial [ISRCTN22931023]

 

In-hospital at day 90

All survivors*

Attribute

Placebo (mean ± SD)

AT III (mean ± SD)

P †

Placebo (mean ± SD) AT III (mean ± SD)

 

P †

Mobility (%)

33 ± 26

38 ± 28

>0.1

49 ± 24

51 ± 24

>0.1

Physical activity (%)

33 ± 27

39 ± 26

>0.1

48 ± 23

50 ± 23

>0.1

Communication/speech (%)

42 ± 42

61 ± 35

0.01

52 ± 34

57 ± 32

0.03

Level of alertness (%)

41 ± 39

59 ± 33

0.02

51 ± 32

56 ± 31

0.02

Energy level (%)

34 ± 27

43 ± 26

0.09

47 ± 23

51 ± 22

0.02

Overall QoL (%)

35 ± 28

44 ± 27

>0.1

51 ± 23

53 ± 23

>0.1

Karnofsky scale (%)

22 ± 19

31 ± 19

0.03

45 ± 19

47 ± 19

>0.1

  1. Scores range from 0 to 100, and changes may range from -100 to +100. Higher scores represent better quality of life (QoL) and increases (i.e. positive changes) represent improvement. *90-day values calculated by last observation carried forward analysis (see text). †Nominal P value for two-sided, two-sample Wilcoxon test for differences between changes from baseline to 90-day QoL. AT, antithrombin.