Figure 1

The effects of glucose administration (2 g/kg, intraperitoneally [i.p.]) on three different parameters. Blood glucose and corticosterone levels in samples taken from one group of rats at the time points indicated after glucose injection, and the degree of ischemic hippocampal damage (as measured 7 days postischemia) in another group of rats administered glucose at the same time points prior to induction of ischemia. Also shown are the effects of either metyrapone (100 g/kg, i.p.) or mifepristone (RU486; 40 mg/kg, i.p.) on the degree of ischemic damage in rats that were administered glucose 15 min preischemia. ^*Significantly different from control, normoglycemic rats (P < 0.05); ^**significantly different from hyperglycemic rats injected with glucose 15 min preischemia (P < 0.05) using an unpaired t test.