Skip to main content

Table 2 Comparison of Outcomes and Differences of Recent Nutrition Delivery Trials in ICU2.

From: Winning the war against ICU-acquired weakness: new innovations in nutrition and exercise physiology

  Trials not supporting goal (>80% kcal/day) nutritional delivery in the ICU Trials supporting goal (> 80% kcal/day) nutritional delivery in the ICU
  EPaNIC (NEJM, 2011) (BB) EDEN Trial (Pilot) (CCM, 2011) (29) Eden Trial (Full RCT) (JAMA, 2012) (28) Arabi Trial (AJCN, 2011) (27) Early PN (JAMA, 2013) (19) TICACOS (ICM, 2011) (AA) SPN (Lancet, 2013) (20) Wei et al. (CCM, 2015) (30)
Age (mean) 64 53 52 51 69 61 61 62
ICU LOS 3.5    13.1 9 12 13 18
Hospital LOS 15     25 25 31.5  
MV days 2 5.6 5 11.9 6.9 10.75 6.64 15
Mortality (%)         
ICU 6.2    19.6   25.4 10 26
Hospital 10.65 21   36 21% 38.3 24 32
Post discharge 11.2   22.7 38.6   47 23  
Primary outcome Sig. reduced LOS in ICU for late PN (median 3 days) vs. early PN (median 4 days) No outcome changes in trophic versus full feeding groups for ventilation days, mortality, or infection No outcome changes in trophic versus full feeding groups for ventilation days, mortality, or infection Nonsig. trend to lower 28-day mortality for trophic (18.3%) compared with target feeding (23.3%) (p <0.07) No sig. change in crude day-60 mortality (standard care (22.8%) vs. early PN (21.5%)) Sig. lower hospital mortality for goal calorie group (28.5%) vs. underfed control group (48.2%) Sig. reduced nosocomial infections for EN + SPN (27%) vs. EN (38%) after day 9 Sig. improved survival and 3-month HRQoL with improved nutrition delivery
Secondary outcome Sig. higher infectious complications, duration of MV, and hospital LOS for early PN Full feeding group more likely to be discharged home than rehabilitation unit (p <0.04) No change in HRQoL at 12 months No difference in LOS or duration of MV Sig. shorter duration of MV Longer duration of MV and ICU LOS, and higher infection rate for goal calorie study group No sig. difference in the ICU LOS, hospital LOS, or mortality Sig. improvement in HRQoL in MICU patients at 3 and 6 months with improved nutrition delivery
      Improved HRQoL for early PN group    
      No change in infection in PN vs. EN    
Protein delivery 0.8 g/kg/day in all patients 0.8 g/kg/day in both groups (including full feed group) 0.6-0.8 g/kg/day in both groups (including full feed group) 0.6 g/kg/day in all patients 1.1-1.2 g/kg/day in early PN group >1.0 g/kg/day in supplemental PN group 1.0-1.1 g/kg/day in supplemental PN group Observational trial
         Protein intake not able to be quantified
  1. All times for length of stays and mechanical ventilation presented in days
  2. Sig. significant, HRQoL health-related quality of life, LOS length of stay, MV mechanical ventilation, PN parenteral nutrition; RCT randomized controlled trial