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Table 1 Microbial products implicated in the pathogenesis of sepsis

From: Bench-to-bedside review: Toll-like receptors and their role in septic shock

Mediator products Host receptor
Lipopolysaccharide LBP-CD14-TLR4-MD2
Peptidoglycan CD14-TLR2, CD14-TLR2/6, CD14-TLR2/1, CD14-TLR2/?
Lipopeptides, lipoteichoic acid CD14-TLR2, CD14-TLR2/6, CD14-TLR2/1, CD14-TLR2/?
Microbial DNA (unmethylated CpG motifs) TLR9
Bacterial flagella TLR5
Double-stranded viral RNA TLR3
  1. LBP, lipopolysaccharide-binding protein; TLR, Toll-like receptor.