Table 1 Microbial products implicated in the pathogenesis of sepsis
From: Bench-to-bedside review: Toll-like receptors and their role in septic shock
Mediator products | Host receptor |
|---|---|
Lipopolysaccharide | LBP-CD14-TLR4-MD2 |
Peptidoglycan | CD14-TLR2, CD14-TLR2/6, CD14-TLR2/1, CD14-TLR2/? |
Lipopeptides, lipoteichoic acid | CD14-TLR2, CD14-TLR2/6, CD14-TLR2/1, CD14-TLR2/? |
Microbial DNA (unmethylated CpG motifs) | TLR9 |
Bacterial flagella | TLR5 |
Double-stranded viral RNA | TLR3 |