In total, 4,516 ICU patients developed at least one episode of hypoglycemia. In three separate multivariate analyses for each of the three measures we adjusted for the respective confounders. The category 80 to 110 mg/dl of the 'highest blood glucose level' was associated with increased mortality compared with the reference category (odds ratio (OR) = 1.31, 95% confidence interval (CI) = 1.06 to 1.61). The lowest quartile of the 'delta glucose' (OR = 1.32, 95% CI = 1.03 to 1.69) and the lowest quartile of the 'standard deviation' (OR = 1.55, 95% CI = 1.23 to 1.96) were associated with higher ICU mortality than their reference categories.