Volume 19 Supplement 1

35th International Symposium on Intensive Care and Emergency Medicine

Open Access

Low serum 25-hydroxyvitamin D at critical care initiation is associated with sepsis and morbidity in Dutch critically ill patients

  • K De Haan1
Critical Care201519(Suppl 1):P365


Published: 16 March 2015


Vitamin D deficiency may frequently occur in critically ill patients and may be associated with sepsis and increased mortality. We therefore evaluated the prevalence of 25-hydroxyvitamin D deficiency in a Dutch ICU, and its relationship with sepsis, morbidity and mortality.


We conducted a prospective observational study in a 10-bed mixed ICU. A total of 1,372 patients were admitted between July 2011 and June 2013 including 198 readmissions, of which 940 patients were studied. 25-Hydroxyvitamin D levels were determined within 24 hours after admission. 25-Hydroxyvitamin D levels were judged as sufficiency (>50 nmol/l), insufficiency (30 to 50 nmol/l) and deficiency (<30 nmol/l).


The prevalence of deficiency and insufficiency was 36% and 38%, respectively. Only 26% of the patients had sufficient vitamin D levels. Vitamin D deficiency is associated with sepsis (P < 0.001) at ICU admission. Patients with deficient levels had higher mean APACHE IV scores, 64 versus 52 (P < 0.001), and longer length of hospital stay, 12 versus 9 days (P < 0.001), respectively, as compared with patients with sufficient levels. Patients with deficient vitamin D levels had an odds ratio for in-hospital mortality of 1.4 (95% confidence interval of 0.84 to 2.29, P = 0.2) relative to patients with sufficient vitamin D levels.


25-Hydroxyvitamin D deficiency frequently occurs in Dutch critically ill patients. Although relating to sepsis, disease severity and morbidity, vitamin D deficiency is not an independent predictor of mortality in these patients, which was otherwise relatively low.

Authors’ Affiliations

Erasmus MC


© Haan et al.; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.