Skip to main content
  • Poster presentation
  • Published:

Performance of amikacin inhale: impact of supplemental oxygen and device orientation


Amikacin Inhale is an integrated drug-device combination in development by Bayer HealthCare through a collaboration with Nektar Therapeutics, to improve clinical outcome in intubated and mechanically ventilated patients with Gram-negative pneumonia. It is available in two configurations: on-vent for intubated patients and hand-held for extubated patients to complete aerosolized antibiotic therapy. Amikacin Inhale is a smart system that consists of the pulmonary drug delivery system with a vibrating mesh nebulizer and the specially formulated Amikacin Inhalation Solution (400 mg every 12 hours for 10 days). The objectives of this study were to evaluate the performance of the Amikacin Inhale hand-held configuration with supplemental O2 concentration supplied at different flow rates and in different orientations. We hypothesize that the delivered dose of amikacin will not significantly change with increased O2 flow rate or varying orientation.


In the hand-held configuration of Amikacin Inhale, amikacin is aerosolized into a holding chamber. Amikacin aerosol is inhaled with ambient air entering the bottom of the chamber through the inhalation valve. Supplemental O2 may be supplied through the O2 port and mixes with ambient air entering through the inhalation valve. O2 concentration and delivered dose at the mouthpiece exit were characterized in vitro at various O2 flow rates (2 to 10 l/minute). O2 concentrations were measured every minute until the end of dosing. A ventilator was connected to the set up to simulate patient breathing. The delivered dose was measured at the exit of the mouthpiece. Drug distribution within the test setup compartments was analyzed using HPLC. The in vitro delivered amikacin dose was also measured at nebulizer orientations of 0° and 45° (n = 3 per orientation) using a simulated breathing profile with no supplemental O2.


The mean O2 concentration ranged from 36 to 70% over 2 to 10 l/minute and was ≥40% at ≥3 l/minute. The delivered dose did not change substantially with increasing enriched O2 flow rate (72 to 82% of nominal dose). At 0° and 45° orientations, the delivered dose of amikacin was 74 to 80% and 73 to 76% of the nominal dose (400 mg), respectively.


Amikacin Inhale was shown in vitro to be suitable for extubated patients who require supplemental O2. The delivered dose was independent of supplemental O2 and device orientation.

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kadrichu, N., Corkery, K., Dang, T. et al. Performance of amikacin inhale: impact of supplemental oxygen and device orientation. Crit Care 19 (Suppl 1), P120 (2015).

Download citation

  • Published:

  • DOI: