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Table 2 Subgroup and sensitivity analyses of filter life and possible confounders a

From: Early mobilization on continuous renal replacement therapy is safe and may improve filter life

Group

Factors

Regression coefficient (robust 95% CI)

P value

Baseline (n = 19)

INR

0.8 (-1.4 to 3.0)

0.44

aPTT

0.1 (-0.3 to 0.5)

0.63

Platelets

0.0 (0.0 to 0.1)

0.09

Positional changes

1.2 (-0.4 to 2.9)

0.13

APACHE III

-0.1 (-0.3 to 0.0)

0.09

Overall cohort (MOVE intervention) (n = 33)

MOVE intervention

13.8 (5.0 to 22.6)

0.003b

Overall subgroup and sensitivity analyses

Passive movements

20.0 (5.4 to 34.6)

0.01b

SOEOB

5.8 (-10.7 to 22.3)

0.46

MOS

18.3 (-1.3 to 37.9)

0.06

INR

9.3 (-2.0 to 20.5)

0.10

aPTT

0.0 (-0.2 to 0.2)

0.86

Platelets

0.0 (-0.1 to 0.0)

0.10

Positional changes

2.0 (0.6 to 3.5)

0.007b

APACHE III

0.1 (0.0 to 0.3)

0.02b

Alarms

-3.1 (-5.0 to -1.2)

0.003b

Femoral subgroup (n =23)

MOVE intervention

15.7 (4.6 to 26.9)

0.008b

Femoral subgroup and sensitivity analyses

Passive movements

20.0 (5.4 to 34.6)

0.01b

SOEOB

8.5 (-20.6 to 37.7)

0.51

MOS

20.5 (-19.9 to 60.9)

0.16

INR

7.6 (-4.9 to 20.0)

0.22

aPTT

-0.1 (-0.2 to 0.1)

0.38

Platelets

0.0 (-0.1 to 0.0)

0.29

Positional changes

2.0 (0.5 to 3.6)

0.01b

APACHE III

0.6 (-0.1 to 0.2)

0.42

Alarms

-7.4 (-13.0 to -1.8)

0.01b

Nonfemoral subgroup (n = 10)

MOVE intervention

9.2 (-6.0 to 24.4)

0.20

Nonfemoral subgroup and sensitivity analyses

Passive movements

N/A

–

SOEOB

1.0 (-12.8 to 14.8)

0.86

MOS

20.6 (-23.3 to 64.4)

0.23

INR

26.4 (7.5 to 45.3)

0.01b

aPTT

0.5 (0.1 to 0.9)

0.03b

Platelets

-0.1 (-0.1 to 0.0)

0.08

Positional changes

1.9 (-1.7 to 5.4)

0.27

APACHE III

0.2 (0.0 to 0.5)

0.05

Alarms

-2.3 (-4.6 to 0.0)

0.05

  1. aAPACHE III: Acute Physiology and Chronic Health Evaluation III; aPTT: Activated partial thromboplastin time; CI: Confidence interval; INR: International normalized ratio; MOS: Marching on the spot; MOVE: Movement on vascular catheter evaluation intervention; N/A: Not applicable; SOEOB: Sitting on edge of bed. Electively ceased filters were excluded from analysis. Twenty-three (17.2%) of one hundred thirty-four femoral filters and fourteen (23.0%) of sixty-one nonfemoral filters were excluded from the filter life analyses, as they were electively ceased. Units of measurement for filter life are hours. Position changes are measured as number per day. Alarms are the number of alarms during the intervention session. bStatistically significant difference.