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Table 2 Subgroup and sensitivity analyses of filter life and possible confounders a

From: Early mobilization on continuous renal replacement therapy is safe and may improve filter life

Group Factors Regression coefficient (robust 95% CI) P value
Baseline (n = 19) INR 0.8 (-1.4 to 3.0) 0.44
aPTT 0.1 (-0.3 to 0.5) 0.63
Platelets 0.0 (0.0 to 0.1) 0.09
Positional changes 1.2 (-0.4 to 2.9) 0.13
APACHE III -0.1 (-0.3 to 0.0) 0.09
Overall cohort (MOVE intervention) (n = 33) MOVE intervention 13.8 (5.0 to 22.6) 0.003b
Overall subgroup and sensitivity analyses Passive movements 20.0 (5.4 to 34.6) 0.01b
SOEOB 5.8 (-10.7 to 22.3) 0.46
MOS 18.3 (-1.3 to 37.9) 0.06
INR 9.3 (-2.0 to 20.5) 0.10
aPTT 0.0 (-0.2 to 0.2) 0.86
Platelets 0.0 (-0.1 to 0.0) 0.10
Positional changes 2.0 (0.6 to 3.5) 0.007b
APACHE III 0.1 (0.0 to 0.3) 0.02b
Alarms -3.1 (-5.0 to -1.2) 0.003b
Femoral subgroup (n =23) MOVE intervention 15.7 (4.6 to 26.9) 0.008b
Femoral subgroup and sensitivity analyses Passive movements 20.0 (5.4 to 34.6) 0.01b
SOEOB 8.5 (-20.6 to 37.7) 0.51
MOS 20.5 (-19.9 to 60.9) 0.16
INR 7.6 (-4.9 to 20.0) 0.22
aPTT -0.1 (-0.2 to 0.1) 0.38
Platelets 0.0 (-0.1 to 0.0) 0.29
Positional changes 2.0 (0.5 to 3.6) 0.01b
APACHE III 0.6 (-0.1 to 0.2) 0.42
Alarms -7.4 (-13.0 to -1.8) 0.01b
Nonfemoral subgroup (n = 10) MOVE intervention 9.2 (-6.0 to 24.4) 0.20
Nonfemoral subgroup and sensitivity analyses Passive movements N/A
SOEOB 1.0 (-12.8 to 14.8) 0.86
MOS 20.6 (-23.3 to 64.4) 0.23
INR 26.4 (7.5 to 45.3) 0.01b
aPTT 0.5 (0.1 to 0.9) 0.03b
Platelets -0.1 (-0.1 to 0.0) 0.08
Positional changes 1.9 (-1.7 to 5.4) 0.27
APACHE III 0.2 (0.0 to 0.5) 0.05
Alarms -2.3 (-4.6 to 0.0) 0.05
  1. aAPACHE III: Acute Physiology and Chronic Health Evaluation III; aPTT: Activated partial thromboplastin time; CI: Confidence interval; INR: International normalized ratio; MOS: Marching on the spot; MOVE: Movement on vascular catheter evaluation intervention; N/A: Not applicable; SOEOB: Sitting on edge of bed. Electively ceased filters were excluded from analysis. Twenty-three (17.2%) of one hundred thirty-four femoral filters and fourteen (23.0%) of sixty-one nonfemoral filters were excluded from the filter life analyses, as they were electively ceased. Units of measurement for filter life are hours. Position changes are measured as number per day. Alarms are the number of alarms during the intervention session. bStatistically significant difference.