Figure 5
Evolution of the hemodynamic parameters at the onset of shock in the septic group before resuscitation therapy. (a) PACvar, variation of the component AC of the photoplethysmographic signal (b) PDCvar, variation of the component DC of the photoplethysmographic signal, (c) MAPvar, variation of the mean arterial pressure, (d) GMvar, variation of the laser Doppler signal on the serosa of the duodenum. T0 is the time of bacterial injection in the septic group (S group) and placebo for the nonseptic group (NS group). Tbr, time before resuscitation is the time for each piglet when MAP decreased to 40 mmHg, which was defined as the shock in our piglet model and triggered resuscitation. Tbs, time before shock is the time exactly 20 minutes before Tbr. ANOVA were performed for each parameter: GM, time effect P = 0.236; PAC, time effect P = 0.067; PDC, time effect P = 0.177; MAP, time effect P = 0.57. The evolution of the PDC and PAC is characterized by a near significant decrease that precedes the decrease of MAP.