Table 3 Performance characteristics of biochemical markers with for predicting acute kidney injury (AKI)

AUC of serum creatinine

0.816*

0.823*

0.881*

0.988*

0.987*

0.898*

 Cut-off value, mg/dL

0.85

0.85

0.85

1.05

1.15

0.95

 Sensitivity

0.710

0.645

0.700

0.926

0.913

0.778

 Specificity

0.706

0743

0.824

0.971

1.000

0.853

AUC of serum cystatin C

0.615

0.54

0.605

0.746*

0.731*

0.619

 Cut-off value, mg/L

0.70

0.75

 Sensitivity

0.704

0.652

 Specificity

0.500

0.618

AUC of plasma NGAL

0.832*

0.905*

0.926*

0.847*

0.818*

0.705*

 Cut-off value, ng/mL

100.5

172.0

159.0

175.5

185.5

144.0

 Sensitivity

0.806

0.806

0.900

0.815

0.739

0.667

 Specificity

0.735

0.800

0.794

0.765

0.912

0.647

AUC of urine NGAL

0.921*

0.927*

0.896*

0.813*

0.914*

0.802*

 Cut-off value, ng/mL

36.6

31.9

26.8

26.8

42.3

52.9

 Sensitivity

0.871

0.871

0.800

0.815

0.870

0.722

 Specificity

0.824

0.829

0.853

0.765

0.824

0.706

(b) Performance characteristics of biochemical markers for predicting late AKI development (n = 59)

Time from admission

0 h

3 h

6 h

12 h

24 h

48 h

AUC of serum creatinine

0.581

0.55

0.609

0.605

0.660*

0.625

 Cut-off value, mg/dL

0.85

 Sensitivity

0.739

 Specificity

0.676

AUC of serum cystatin C

0.488

0.437

0.545

0.491

0.513

0.444

AUC of plasma NGAL

0.682*

0.658*

0.670*

0.605

0.571

0.537

 Cut-off value, ng/mL

102.5

100.0

125.0

 Sensitivity

0.640

0.583

0.625

 Specificity

0.735

0.629

0.676

AUC of urine NGAL

0.692*

0.681*

0.644

0.599

0.598

0.604

 Cut-off value, ng/mL

11.95

7.25

8.25

 Sensitivity

0.680

0.708

0.625

 Specificity

0.647

0.600

0.588