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Table 2 Linezolid pharmacokinetic parameters following intravenous administration of 600 mg twice daily in critically ill ICU patients

From: Variability of linezolid concentrations after standard dosing in critically ill patients: a prospective observational study

Patient number

AUC24(mg*h/L)a

Cmin(mg/L)b

1

99.1

0.67

2

50.1

<0.13c

3

258.2

3.35

4

118.3

1.89

5

82.3

0.46

6

213.7

3.15

7

206.3

3.59

8

138.9

1.17

9

453.9

13.75

10

165.3

3.26

11

105.3

0.43

12

224.7

4.13

13

67.6

0.14

14

266.9

2.31

15

80.8

0.70

16

101.7

0.18

17

442.0

14.49

18

325.6

2.75

19

217.8

3.48

20

94.8

<0.13

21

122.0

1.03

22

144.6

3.70

23

141.8

2.22

24

250.8

8.18

25

157.1

1.45

26

50.8

<0.13

27

165.1

4.22

28

106.2

0.17

29

86.5

0.45

30

244.1

5.86

Median

143.3

2.06

Range

50.1 to 453.9

<0.13 to 14.49

  1. aAs determined by the NONMEM system, values from the start of the third administration of linezolid over 24 h; bas analyzed by liquid chromatography tandem mass spectrometry, values obtained directly before the fourth administration of linezolid if not indicated otherwise;
  2. cvalue obtained directly before the fifth administration of linezolid. AUC24, concentration time curve over 24 h; Cmin, linezolid trough level.
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Critical Care

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