Table 2 Characteristics of 1-month survivors and non-survivors among patients with sepsis
Survivors (n = 130) | Non-survivors (n = 68) | P-value | |
|---|---|---|---|
Gender, male, n (%) | 89 (68.5) | 41 (60.3) | 0.27 |
Age, years, median ( 25th, 75th percentile) | 54 (44, 64) | 61 (50, 72) | 0.11 |
Diabetes mellitus, n (%) | 33 (25.4) | 24 (35.3) | 0.19 |
COPD, n (%) | 15 (11.5) | 9 (13.2) | 0.82 |
Ischemic heart disease, n (%) | 13 (10.0) | 7 (10.3) | 0.99 |
Chronic renal failure, n (%) | 6 (4.6) | 7 (10.3) | 0.14 |
Site of infection, n (%) | 0.40 | ||
Respiratory | 72 (55.4) | 40 (58.8) | |
Abdominal | 39 (30.0) | 18 (26.5) | |
Neurological | 2 (1.5) | 1 (1.5) | |
Urinary | 8 (6.2) | 2 (2.9) | |
Skin | 6 (4.6) | 1 (1.5) | |
Endocarditis | 3 (2.3) | 5 (7.3) | |
Osteomyelitis | 0 | 1 (1.5) | |
Microorganism responsible, n (%) | |||
Unknown | 68 (52.3) | 35 (51.5) | 0.99 |
Gram-positive | 28 (21.5) | 19 (27.9) | 0.38 |
Gram-negative | 32 (24.6) | 14 (20.6) | 0.60 |
Fungii | 3 (2.3) | 3 (4.4) | 0.42 |
Anaerobe | 1 (0.8) | 1 (1.5) | 0.99 |
Bloodstream infection, n (%) | 20 (15.4) | 11 (16.2) | 0.99 |
Empiric antimicrobial treatment, n (%) | 0.89 | ||
Unknown if adequate due to negative cultures | 65 (50.0) | 33 (48.5) | |
Unknown if adequate due to diagnosis by antigenuria | 4 (3.1) | 3 (4.4) | |
Adequate | 55 (42.3) | 30 (44.1) | |
Inadequate | 6 (4.6) | 2 (2.9) | |
Betalactamic more aminoglycoside, n (%) | 26 (20.0) | 16 (23.5) | 0.59 |
Aminoglycoside, n (%) | 36 (27.7) | 18 (26.5) | 0.99 |
Betalactamic more quinolone, n (%) | 70 (53.8) | 36 (52.9) | 0.99 |
Septic shock, n (%) | 109 (83.8) | 62 (91.2) | 0.19 |
PaO2/FIO2 ratio, median (25th, 75th percentile) | 159 (105, 260) | 168 (109, 237) | 0.58 |
Creatinine, mg/dl , median (25th, 75th percentile) | 1.10 (0.80, 1.90) | 1.60 (0.90, 2.65) | 0.08 |
Bilirubin, mg/dl, median (25th, 75th percentile) | 0.90 (0.40, 1.55) | 0.88 (0.47, 2.54) | 0.63 |
Leukocytes, cells/μl, median*103 (25th, 75th percentile) | 14.0 (8.6, 21.5) | 15.1 (6.4, 20.2) | 0.84 |
Lactic acid, mmol/l, median (25th, 75th percentile) | 1.80 (1.20, 3.50) | 3.80 (1.55, 6.25) | <0.001 |
Platelets, cells/μl, median*103 (25th, 75th percentile) | 192 (112, 267) | 124 (64, 196) | 0.01 |
INR, median (25th, 75th percentile) | 1.26 (1.10, 1.50) | 1.42 (1.15, 1.68) | 0.03 |
aPTT, seconds, median (25th, 75th percentile) | 32 (28, 37) | 38 (29, 45) | 0.01 |
APACHE-II score, median (25th, 75th percentile) | 18 (14, 23) | 23 (17, 28) | <0.001 |
SOFA score, median (25th, 75th percentile) | 9 (7, 12) | 11 (9, 14) | 0.001 |