Presence of Candida cell wall derived polysaccharides in the sera of intensive care unit patients: relation with candidaemia and Candida colonisation

Table 2 Sensitivity, specificity and likelihood ratios for glucanaemia and mannanaemia

	Sensitivity		Specificity		Positive LR		Negative LR
	Week -8/+8	Day –7/+7	Week -8/+8	Day –7/+7	Week -8/+8	Day –7/+7	Week -8/+8	Day –7/+7
β-d- 1,3-glucan	100	97.1	30.6	30.6	1.4	1.4	0	0.1
Mannan	38.5	32.3	95.8	95.8	9.2	7.7	0.6	0.7
Mannan antibody	58.1	52.9	66.2	66.2	1.7	1.6	0.6	0.7
Mannan or mannan antibody	79.5	58.8	66.2	64.8	2.4	1.7	0.3	0.6

Sensitivity, specificity and positive and negative likelihood ratios (LRs) for glucanaemia (β-d- 1,3-glucan), mannanaemia and anti-mannan antibody detection tests, as well as a combination of mannan/mannan antibody, during the whole period of serum collection (week 8 before to week 8 after the first positive blood culture (Week -8/+8)), and the critical period for diagnosis (day 7 before to day 7 after the first positive blood culture (Day –7/+7)).

ISSN: 1364-8535