Beta-lactam dosing in critically ill patients with septic shock and continuous renal replacement therapy

Table 6 Available data on ceftriaxone pharmacokinetics in hemofiltration

	Sieving coefficient^a	Type of pharmacokinetic analysis	Total CL (l/hour)^a	Vd (l/kg)^a	Residual diuresis (ml/24 hours)^a	Clinical outcome	Authors’ dose recommendation	Study limitations
Spanish product information	N/A	N/R	0.6 to 1.2	0.10 to 0.17	N/A	N/A	N/A	N/A
Garot and colleagues [36]	N/R	Two compartments	0.97 (for low CrCL = 5.5 ml/minute)	0.26 (for a 70 kg adult, weight N/R)	N/R, CrCL range 5.5 to 214 ml/minute	100 % attainment of 100 % T_>MIC	No dose adjustment	No report of severity scores, RRT settings, residual diuresis and CrCL estimation method, unbound concentration calculated using a formula, heterogenic population
Kroh and colleagues [37]	0.69 ± 0.39	Noncompartmental	2.36	0.42 ± 0.19	N/R, CrCL range 0 to 10 ml/minute	N/R	No dose adjustment	No residual diuresis and CrCL estimation method reported. No outcomes study performed, no septic shock, no albumin concentrations considered

The table includes healthy volunteers’ data with comparative purpose. CL, clearance; CrCL, creatinine clearance; N/A, not applicable; N/R, not reported; RRT, renal replacement therapy; %T_>MIC, percentage of dosing interval while concentration of the antibiotic is above the minimum inhibitory concentration of the pathogen; Vd, volume of distribution. ^aData presented as mean ± standard deviation or median (25 to 75 % range).

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