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Table 3 Severity of H1N1pdm infection in hospitalized patients regarding missense single-nucleotide polymorphisms of SFTPA2 and SFTPA1

From: Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection

    

Statistical significance

   

P a

P b

P a

P b

   

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

Polymorphism

Genotype frequencies

Genotype comparisons

Allele comparisons

rs1965708 (Q223K)

CC

CA

AA

CC vs CA + AA

C vs A

 ARF

48

33 (0.69)

15 (0.31)

0 (0.00)

0.027

0.018

0.006

0.006

 No ARF

22

9 (0.41)

10 (0.46)

3 (0.14)

3.18 (1.12-9.01)

5.40 (1.34-21.71)

3.09 (1.35-7.04)

4.09 (1.5-11.13)

 ARDS

16

14 (0.88)

2 (0.13)

0 (0.00)

0.018c

0.017

0.014

0.006

 No ARDS

54

28 (0.52)

23 (0.43)

3 (0.06)

6.45 (1.35-31.25)

7.81 (1.45-42.05)

5.51 (1.24-24.51)

17.68 (2.25-138.57)

 Shock

16

14 (0.88)

2 (0.13)

0 (0.00)

0.018c

0.018

0.014

0.007

 No shock

54

28 (0.52)

23 (0.43)

3 (0.06)

6.45 (1.35-31.25)

7.64 (1.41-41.44)

5.51 (1.24-24.51)

17.16 (2.17-135.70)

 MV

24

20 (0.83)

4 (0.17)

0 (0.00)

0.004

0.007

0.004

0.003

 No MV

46

22 (0.48)

21 (0.46)

3 (0.07)

5.46 (1.61-18.47)

18.60 (2.23-155.24)

4.57 (1.49-13.97)

12.78 (2.39-68.42)

 ICUe

30

23 (0.77)

7 (0.23)

0 (0.00)

0.014

0.019

0.010

0.031

 No ICUe

40

19 (0.48)

18 (0.45)

3 (0.08)

3.64 (1.27-10.42)

2.98 (1.19-7.46)

3.25 (1.29-8.16)

2.43 (1.09-5.45)

rs1059046 (T9N)

AA

AC

CC

AA vs AC + CC

A vs C

 ARF

48

20 (0.42)

24 (0.50)

4 (0.08)

0.020

0.011

0.017

0.005

 No ARF

22

3 (0.14)

14 (0.64)

5 (0.23)

4.52 (1.18-17.24)

8.02 (1.61-39.98)

2.40 (1.16-4.98)

3.70 (1.48-9.30)

 ARDS

16

9 (0.56)

6 (0.38)

1 (0.06)

0.023

0.014

-

0.016

 No ARDS

54

14 (0.26)

32 (0.59)

8 (0.15)

3.68 (1.15-11.77)

5.47 (1.42-21.13)

-

3.71 (1.28-10.72)

 MV

24

11 (0.46)

12 (0.50)

1 (0.04)

-

0.039

-

0.016

 No MV

46

12 (0.26)

26 (0.57)

8 (0.17)

-

3.59 (1.07-12.10)

-

2.97 (1.22-7.19)

 ICUe

30

14 (0.47)

14 (0.47)

2 (0.07)

0.033

-

0.036

-

 No ICUe

40

9 (0.23)

24 (0.60)

7 (0.18)

3.01 (1.07-8.48)

-

2.11 (1.04-4.27)

-

rs1136450 (L50V)

GG

GC

CC

CC vs GC + GG

G vs C

 ARF

48

21 (0.44)

25 (0.52)

2 (0.04)

0.028c

0.019

0.024

0.038

 No ARF

22

5 (0.23)

12 (0.55)

5 (0.23)

6,77 (1.20-38.22)

19.80 (1.64-238.70)

2.31 (1.11-4.81)

2.60 (1.05-6.42)

 MV

24

11 (0.46)

13 (0.54)

0 (0.00)

0.044

-

-

0.040

 No MV

46

15 (0.33)

24 (0.52)

7 (0.15)

1.62 (1.33-1.96)

-

-

2.55 (1.04-6.22)

  1. aP value for the bivariate comparison calculated with the χ2 test. bP value for the multivariate analysis calculated with binary logistic regression, including the variables age, gender, risk factors, secondary bacterial pneumonia, and bacteremia. cap value by Fisher Exact test. dip value for the multivariate analysis calculated with binary logistic regression, including the variables age, gender, risk factors, and secondary bacterial pneumonia (bacteremia variable was excluded because it shows a co-lineal relation with the variable mechanical ventilation). ePatients who required (ICU) or did not require (No ICU) ICU admission, P value for the multivariate analysis calculated with conditional logistic regression stratified by hospital of origin, including the co variables age, gender, risk factors, secondary bacterial pneumonia, and bacteremia. Only those comparisons with P < 0.05 and significant odds ratios were included. OR (95% CI), Odds ratio (95% confidence interval); ARF, acute respiratory failure; ARDS, acute respiratory distress syndrome; MV, mechanical ventilation; ICU, intensive care unit.
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