IgM transcriptomic response in the presence/absence of sepsis. Left: comparison of immunoglobulin (Ig)M transcriptomic response between groups. HC, healthy control (n = 15); SIRS, systemic inflammatory response syndrome (n = 20); SEPSIS SOFA < =10, Sepsis with Sepsis-related Organ Failure Assessment score ≤10 (n = 39); SEPSIS SOFA >10, sepsis with SOFA score >10 (n = 16). Results for the ratio are expressed as (Copies IGHM/Copies CD20). Right: receiver operating characteristic curve of IGHM/CD20 predicting presence of sepsis in the comparison (sepsis versus SIRS). For this comparison septic patients were considered as a single group.