Prognostic and diagnostic value of eosinopenia, C-reactive protein, procalcitonin, and circulating cell-free DNA in critically ill patients admitted with suspicion of sepsis

Table 2 Clinical performance of biomarkers in diagnosing sepsis

	Leukocytes		CRP		PCT		cf-DNA		Eosinophils
	Day 1	Day 2	Day 1	Day 2	Day 1	Day 2	Day 1	Day 2	Day 1	Day 2
Sensitivity (%)	64.96	78.26	90.60	93.91	91.38	81.03	79.31	67.24	64.96	54.87
Specificity (%)	34.88	32.56	40.48	30.95	67.44	67.44	30.23	39.53	28.57	42.50
PPV (%)	73.08	75.63	80.92	78.83	88.33	87.04	75.41	75.00	71.70	72.94
NPV (%)	26.79	35.90	60.71	65.00	74.36	56.86	35.14	30.91	22.64	25.00

cf-DNA, cell-free DNA; CRP, C-reactive protein; NPV, negative predictive value; PCT, procalcitonin; PPV, positive predictive value.
Cutoff values were determined using the Youden index: leukocytes > 11 × 10⁹ cells/l, CRP > 10.38 mg/dl, PCT > 1.39 ng/ml, cf-DNA > 2,850 GE/ml, and eosinophils <25 cells/mm³.

ISSN: 1364-8535